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DOI | 10.1029/2018JD028500 |
Integration of temporal and spatial patterning generates neural diversity | |
Erclik, Ted1,2; Li, Xin1,6; Courgeon, Maximilien1; Bertet, Claire1; Chen, Zhenqing1; Baumert, Ryan1; Ng, June1; Koo, Clara1; Arain, Urfa2; Behnia, Rudy1; Rodriguez, Alberto Del Valle3; Senderowicz, Lionel4,5; Negre, Nicolas4,5; White, Kevin P.4,5; Desplan, Claude1,3 | |
2017-01-19 | |
发表期刊 | NATURE |
ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2017 |
卷号 | 541期号:7637页码:365-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Canada; U Arab Emirates |
英文摘要 | In the Drosophila optic lobes, 800 retinotopically organized columns in the medulla act as functional units for processing visual information. The medulla contains over 80 types of neuron, which belong to two classes: uni-columnar neurons have a stoichiometry of one per column, while multi-columnar neurons contact multiple columns. Here we show that combinatorial inputs from temporal and spatial axes generate this neuronal diversity: all neuroblasts switch fates over time to produce different neurons; the neuroepithelium that generates neuroblasts is also subdivided into six compartments by the expression of specific factors. Uni-columnar neurons are produced in all spatial compartments independently of spatial input; they innervate the neuropil where they are generated. Multi-columnar neurons are generated in smaller numbers in restricted compartments and require spatial input; the majority of their cell bodies subsequently move to cover the entire medulla. The selective integration of spatial inputs by a fixed temporal neuroblast cascade thus acts as a powerful mechanism for generating neural diversity, regulating stoichiometry and the formation of retinotopy. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000396128800036 |
WOS关键词 | DROSOPHILA OPTIC LOBE ; CENTRAL-NERVOUS-SYSTEM ; GENE-EXPRESSION ; VISUAL CENTER ; NEUROBLASTS ; IDENTITY ; NOTCH ; MELANOGASTER ; MEDULLA ; BRAIN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/33760 |
专题 | 气候变化 |
作者单位 | 1.NYU, Dept Biol, New York, NY 10003 USA; 2.Univ Toronto, Dept Biol, Mississauga, ON L5L 1C6, Canada; 3.New York Univ Abu Dhabi, Ctr Genom & Syst Biol, Abu Dhabi, U Arab Emirates; 4.Univ Chicago, Inst Genom & Syst Biol, Chicago, IL 60637 USA; 5.Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA; 6.Univ Illinois, Dept Cell & Dev Biol, Urbana, IL 61801 USA |
推荐引用方式 GB/T 7714 | Erclik, Ted,Li, Xin,Courgeon, Maximilien,et al. Integration of temporal and spatial patterning generates neural diversity[J]. NATURE,2017,541(7637):365-+. |
APA | Erclik, Ted.,Li, Xin.,Courgeon, Maximilien.,Bertet, Claire.,Chen, Zhenqing.,...&Desplan, Claude.(2017).Integration of temporal and spatial patterning generates neural diversity.NATURE,541(7637),365-+. |
MLA | Erclik, Ted,et al."Integration of temporal and spatial patterning generates neural diversity".NATURE 541.7637(2017):365-+. |
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