Malaria infection and severe disease risks in Africa

doi:10.1126/science.abj0089

GSTDTAP > 气候变化

DOI	10.1126/science.abj0089
	Malaria infection and severe disease risks in Africa
	Robert S. Paton; Alice Kamau; Samuel Akech; Ambrose Agweyu; Morris Ogero; Charles Mwandawiro; Neema Mturi; Shebe Mohammed; Arthur Mpimbaza; Simon Kariuki; Nancy A. Otieno; Bryan O. Nyawanda; Amina F. Mohamed; George Mtove; Hugh Reyburn; Sunetra Gupta; Philip Bejon; José Lourenço; Robert W. Snow
	2021-08-20
发表期刊	Science
出版年	2021
英文摘要	Understanding how changes in community parasite prevalence alter the rate and age distribution of severe malaria is essential for optimizing control efforts. Paton et al. assessed the incidence of pediatric severe malaria admissions from 13 hospitals in East Africa from 2006 to 2020 (see the Perspective by Taylor and Slutsker). Each 25% increase in community parasite prevalence shifted hospital admissions toward younger children. Low rates of lifetime infections appeared to confer some immunity to severe malaria in very young children. Children under the age of 5 years thus need to remain a focus of disease prevention for malaria control. Science , abj0089, this issue p. [926][1]; see also abk3443, p. [855][2] The relationship between community prevalence of Plasmodium falciparum and the burden of severe, life-threatening disease remains poorly defined. To examine the three most common severe malaria phenotypes from catchment populations across East Africa, we assembled a dataset of 6506 hospital admissions for malaria in children aged 3 months to 9 years from 2006 to 2020. Admissions were paired with data from community parasite infection surveys. A Bayesian procedure was used to calibrate uncertainties in exposure (parasite prevalence) and outcomes (severe malaria phenotypes). Each 25% increase in prevalence conferred a doubling of severe malaria admission rates. Severe malaria remains a burden predominantly among young children (3 to 59 months) across a wide range of community prevalence typical of East Africa. This study offers a quantitative framework for linking malaria parasite prevalence and severe disease outcomes in children. [1]: /lookup/doi/10.1126/science.abj0089 [2]: /lookup/doi/10.1126/science.abk3443
领域	气候变化 ; 资源环境
URL	查看原文
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文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/336037
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Robert S. Paton,Alice Kamau,Samuel Akech,et al. Malaria infection and severe disease risks in Africa[J]. Science,2021.
APA	Robert S. Paton.,Alice Kamau.,Samuel Akech.,Ambrose Agweyu.,Morris Ogero.,...&Robert W. Snow.(2021).Malaria infection and severe disease risks in Africa.Science.
MLA	Robert S. Paton,et al."Malaria infection and severe disease risks in Africa".Science (2021).