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DOI | 10.1289/EHP7877 |
Chronic Manganese Exposure and the Enteric Nervous System: An in Vitro and Mouse in Vivo Study | |
Shivani Ghaisas; Dilshan S. Harischandra; Bharathi Palanisamy; Alexandra Proctor; Huajun Jin; Somak Dutta; Souvarish Sarkar; Monica Langley; Gary Zenitsky; Vellareddy Anantharam; Arthi Kanthasamy; Gregory J. Phillips; Anumantha Kanthasamy | |
2021-08-19 | |
发表期刊 | Environmental Health Perspectives |
出版年 | 2021 |
英文摘要 | AbstractBackground:Chronic environmental exposure to manganese (Mn) can cause debilitating damage to the central nervous system. However, its potential toxic effects on the enteric nervous system (ENS) have yet to be assessed. Objective:We examined the effect of Mn on the ENS using both cell and animal models. Method:Rat enteric glial cells (EGCs) and mouse primary enteric cultures were exposed to increasing concentrations of Mn and cell viability and mitochondrial health were assessed using various morphological and functional assays. C57BL/6 mice were exposed daily to a sublethal dose of Mn () for 30 d. Gut peristalsis, enteric inflammation, gut microbiome profile, and fecal metabolite composition were assessed at the end of exposure. Results:EGC mitochondria were highly susceptible to Mn neurotoxicity, as evidenced by lower mitochondrial mass, adenosine triphosphate–linked respiration, and aconitase activity as well as higher mitochondrial superoxide, upon Mn exposure. Minor differences were seen in the mouse model: specifically, longer intestinal transit times and higher levels of colonic inflammation. Conclusion:Based on our findings from this study, Mn preferentially induced mitochondrial dysfunction in a rat EGC line and in vivo resulted in inflammation in the ENS. https://doi.org/10.1289/EHP7877 |
领域 | 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/335921 |
专题 | 资源环境科学 |
推荐引用方式 GB/T 7714 | Shivani Ghaisas,Dilshan S. Harischandra,Bharathi Palanisamy,et al. Chronic Manganese Exposure and the Enteric Nervous System: An in Vitro and Mouse in Vivo Study[J]. Environmental Health Perspectives,2021. |
APA | Shivani Ghaisas.,Dilshan S. Harischandra.,Bharathi Palanisamy.,Alexandra Proctor.,Huajun Jin.,...&Anumantha Kanthasamy.(2021).Chronic Manganese Exposure and the Enteric Nervous System: An in Vitro and Mouse in Vivo Study.Environmental Health Perspectives. |
MLA | Shivani Ghaisas,et al."Chronic Manganese Exposure and the Enteric Nervous System: An in Vitro and Mouse in Vivo Study".Environmental Health Perspectives (2021). |
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