Immunotherapy: Building a bridge to a cure for type 1 diabetes

doi:10.1126/science.abh1654

GSTDTAP > 气候变化

DOI	10.1126/science.abh1654
	Immunotherapy: Building a bridge to a cure for type 1 diabetes
	Jeffrey A. Bluestone; Jane H. Buckner; Kevan C. Herold
	2021-07-30
发表期刊	Science
出版年	2021
英文摘要	Type 1 diabetes (T1D) is an autoimmune disease in which T cells attack and destroy the insulin-producing β cells in the pancreatic islets. Genetic and environmental factors increase T1D risk by compromising immune homeostasis. Although the discovery and use of insulin have transformed T1D treatment, insulin therapy does not change the underlying disease or fully prevent complications. Over the past two decades, research has identified multiple immune cell types and soluble factors that destroy insulin-producing β cells. These insights into disease pathogenesis have enabled the development of therapies to prevent and modify T1D. In this review, we highlight the key events that initiate and sustain pancreatic islet inflammation in T1D, the current state of the immunological therapies, and their advantages for the treatment of T1D.
领域	气候变化 ; 资源环境
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/335506
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Jeffrey A. Bluestone,Jane H. Buckner,Kevan C. Herold. Immunotherapy: Building a bridge to a cure for type 1 diabetes[J]. Science,2021.
APA	Jeffrey A. Bluestone,Jane H. Buckner,&Kevan C. Herold.(2021).Immunotherapy: Building a bridge to a cure for type 1 diabetes.Science.
MLA	Jeffrey A. Bluestone,et al."Immunotherapy: Building a bridge to a cure for type 1 diabetes".Science (2021).