Global S&T Development Trend Analysis Platform of Resources and Environment
| DOI | 10.1126/science.abi4742 |
| Preventing type 1 diabetes in childhood | |
| Colin M. Dayan; Rachel E. J. Besser; Richard A. Oram; William Hagopian; Manu Vatish; Owen Bendor-Samuel; Matthew D. Snape; John A. Todd | |
| 2021-07-30 | |
| 发表期刊 | Science
 |
| 出版年 | 2021 |
| 英文摘要 | Type 1 diabetes (T1D) is an autoimmune disease in which the insulin-producing β cells of the pancreas are destroyed by T lymphocytes. Recent studies have demonstrated that monitoring for pancreatic islet autoantibodies, combined with genetic risk assessment, can identify most children who will develop T1D when they still have sufficient β cell function to control glucose concentrations without the need for insulin. In addition, there has been recent success in secondary prevention using immunotherapy to delay the progression of preclinical disease, and primary prevention approaches to inhibiting the initiating autoimmune process have entered large-scale clinical trials. By changing the focus of T1D management from late diagnosis and insulin replacement to early diagnosis and β cell preservation, we can anticipate a future without the need for daily insulin injections for children with T1D. |
| 领域 | 气候变化 ; 资源环境 |
| URL | 查看原文 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/335503 |
| 专题 | 气候变化 资源环境科学 |
| 推荐引用方式 GB/T 7714 | Colin M. Dayan,Rachel E. J. Besser,Richard A. Oram,et al. Preventing type 1 diabetes in childhood[J]. Science,2021. |
| APA | Colin M. Dayan.,Rachel E. J. Besser.,Richard A. Oram.,William Hagopian.,Manu Vatish.,...&John A. Todd.(2021).Preventing type 1 diabetes in childhood.Science. |
| MLA | Colin M. Dayan,et al."Preventing type 1 diabetes in childhood".Science (2021). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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