Astrocytes close the mouse critical period for visual plasticity

doi:10.1126/science.abf5273

GSTDTAP > 气候变化

DOI	10.1126/science.abf5273
	Astrocytes close the mouse critical period for visual plasticity
	Jérôme Ribot; Rachel Breton; Charles-Félix Calvo; Julien Moulard; Pascal Ezan; Jonathan Zapata; Kevin Samama; Matthieu Moreau; Alexis-Pierre Bemelmans; Valentin Sabatet; Florent Dingli; Damarys Loew; Chantal Milleret; Pierre Billuart; Glenn Dallérac; Nathalie Rouach
	2021-07-02
发表期刊	Science
出版年	2021
英文摘要	During the visual critical period, brain circuits are rewired to adjust to sensory input. Closure of the critical period stabilizes the circuits. Looking at development in the mouse visual cortex, Ribot et al. found that astrocytes increase their expression of the gap junction channel subunit connexin 30, which in turn inhibits expression of a matrix-degrading enzyme (see the Perspective by Kofuji and Araque). As the matrix stabilizes, inhibitory interneurons mature, and the unusual flexibility of the critical period comes to an end. Science , abf5273, this issue p. [77][1]; see also abj6745, p. [29][2] Brain postnatal development is characterized by critical periods of experience-dependent remodeling of neuronal circuits. Failure to end these periods results in neurodevelopmental disorders. The cellular processes defining critical-period timing remain unclear. Here, we show that in the mouse visual cortex, astrocytes control critical-period closure. We uncover the underlying pathway, which involves astrocytic regulation of the extracellular matrix, allowing interneuron maturation. Unconventional astrocyte connexin signaling hinders expression of extracellular matrix–degrading enzyme matrix metalloproteinase 9 (MMP9) through RhoA–guanosine triphosphatase activation. Thus, astrocytes not only influence the activity of single synapses but also are key elements in the experience-dependent wiring of brain circuits. [1]: /lookup/doi/10.1126/science.abf5273 [2]: /lookup/doi/10.1126/science.abj6745
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/334182
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Jérôme Ribot,Rachel Breton,Charles-Félix Calvo,et al. Astrocytes close the mouse critical period for visual plasticity[J]. Science,2021.
APA	Jérôme Ribot.,Rachel Breton.,Charles-Félix Calvo.,Julien Moulard.,Pascal Ezan.,...&Nathalie Rouach.(2021).Astrocytes close the mouse critical period for visual plasticity.Science.
MLA	Jérôme Ribot,et al."Astrocytes close the mouse critical period for visual plasticity".Science (2021).