Why identical mutations cause different types of cancer

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	Why identical mutations cause different types of cancer
	admin
	2021-07-19
发布年	2021
语种	英语
国家	德国
领域	资源环境
正文(英文)	Why do alterations of certain genes cause cancer only in specific organs of the human body? Scientists at the German Cancer Consortium (DKTK), the Technical University of Munich (TUM), and the University Medical Center Göttingen have now demonstrated that cells originating from different organs are differentially susceptible to activating mutations in cancer drivers: The same mutation in precursor cells of the pancreas or the bile duct leads to fundamental different outcomes. The team discovered for the first time that tissue specific genetic interactions are responsible for the differential susceptibility of the biliary and the pancreatic epithelium towards transformation by oncogenes. The new findings could guide more precise therapeutic decision making in the future.
URL	查看原文
来源平台	Helmholtz Association
文献类型	新闻
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/333513
专题	资源环境科学
推荐引用方式 GB/T 7714	admin. Why identical mutations cause different types of cancer. 2021.