NF-κB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages

doi:10.1126/science.abc0269

GSTDTAP > 气候变化

DOI	10.1126/science.abc0269
	NF-κB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages
	Quen J. Cheng; Sho Ohta; Katherine M. Sheu; Roberto Spreafico; Adewunmi Adelaja; Brooks Taylor; Alexander Hoffmann
	2021-06-18
发表期刊	Science
出版年	2021
英文摘要	Different temporal dynamics of activation of the transcription factor nuclear factor κB (NF-κB) can influence the inflammatory response of activated macrophages. Cheng et al. report a mechanism by which oscillatory and sustained NF-κB signaling may produce distinct transcriptional responses (see the Perspective by Nandagopal et al. ). Oscillatory activation of NF-κB activated poised enhancers to transcribe inflammatory genes in mouse macrophages. However, sustained activation of NF-κB produced in cells activated by other stimuli acted on the epigenome. These stimuli relieved chromatin silencing at enhancers and enabled regulation of additional genes. Science , abc0269, this issue p. [1349][1]; see also abj2040, p. [1263][2] The epigenome of macrophages can be reprogrammed by extracellular cues, but the extent to which different stimuli achieve this is unclear. Nuclear factor κB (NF-κB) is a transcription factor that is activated by all pathogen-associated stimuli and can reprogram the epigenome by activating latent enhancers. However, we show that NF-κB does so only in response to a subset of stimuli. This stimulus specificity depends on the temporal dynamics of NF-κB activity, in particular whether it is oscillatory or non-oscillatory. Non-oscillatory NF-κB opens chromatin by sustained disruption of nucleosomal histone–DNA interactions, enabling activation of latent enhancers that modulate expression of immune response genes. Thus, temporal dynamics can determine a transcription factor’s capacity to reprogram the epigenome in a stimulus-specific manner. [1]: /lookup/doi/10.1126/science.abc0269 [2]: /lookup/doi/10.1126/science.abj2040
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/330816
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Quen J. Cheng,Sho Ohta,Katherine M. Sheu,et al. NF-κB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages[J]. Science,2021.
APA	Quen J. Cheng.,Sho Ohta.,Katherine M. Sheu.,Roberto Spreafico.,Adewunmi Adelaja.,...&Alexander Hoffmann.(2021).NF-κB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages.Science.
MLA	Quen J. Cheng,et al."NF-κB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages".Science (2021).