Cell size controlled in plants using DNA content as an internal scale

doi:10.1126/science.abb4348

GSTDTAP > 气候变化

DOI	10.1126/science.abb4348
	Cell size controlled in plants using DNA content as an internal scale
	Marco D’Ario; Rafael Tavares; Katharina Schiessl; Bénédicte Desvoyes; Crisanto Gutierrez; Martin Howard; Robert Sablowski
	2021-06-11
发表期刊	Science
出版年	2021
英文摘要	In the Arabidopsis meristem, cell sizes are regularized despite asymmetric cell divisions. D'Ario et al. describe a balanced regulatory system that controls the duration of the growth phase of the cell cycle preceding DNA synthesis. KIP-related protein 4 (KRP4) inhibits progression to DNA synthesis. Because the amount of KRP4, which binds to mitotic chromosomes, is titrated to the amount of chromosomal DNA, daughter cells begin with similar amounts of KRP4 despite possible asymmetric cell divisions. Deviations are adjusted as excess KRP4 is degraded and the cell size is normalized. Science , abb4348, this issue p. [1176][1] How eukaryotic cells assess and maintain sizes specific for their species and cell type remains unclear. We show that in the Arabidopsis shoot stem cell niche, cell size variability caused by asymmetric divisions is corrected by adjusting the growth period before DNA synthesis. KIP-related protein 4 (KRP4) inhibits progression to DNA synthesis and associates with mitotic chromosomes. The F BOX-LIKE 17 (FBL17) protein removes excess KRP4. Consequently, daughter cells are born with comparable amounts of KRP4. Inhibitor dilution models predicted that KRP4 inherited through chromatin would robustly regulate size, whereas inheritance of excess free KRP4 would disrupt size homeostasis, as confirmed by mutant analyses. We propose that a cell cycle regulator, stabilized by association with mitotic chromosomes, reads DNA content as a cell size–independent scale. [1]: /lookup/doi/10.1126/science.abb4348
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/329909
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Marco D’Ario,Rafael Tavares,Katharina Schiessl,et al. Cell size controlled in plants using DNA content as an internal scale[J]. Science,2021.
APA	Marco D’Ario.,Rafael Tavares.,Katharina Schiessl.,Bénédicte Desvoyes.,Crisanto Gutierrez.,...&Robert Sablowski.(2021).Cell size controlled in plants using DNA content as an internal scale.Science.
MLA	Marco D’Ario,et al."Cell size controlled in plants using DNA content as an internal scale".Science (2021).