Reciprocal repulsions instruct the precise assembly of parallel hippocampal networks

doi:10.1126/science.abg1774

GSTDTAP > 气候变化

DOI	10.1126/science.abg1774
	Reciprocal repulsions instruct the precise assembly of parallel hippocampal networks
	Daniel T. Pederick; Jan H. Lui; Ellen C. Gingrich; Chuanyun Xu; Mark J. Wagner; Yuanyuan Liu; Zhigang He; Stephen R. Quake; Liqun Luo
	2021-06-04
发表期刊	Science
出版年	2021
英文摘要	Brain circuits established during development can be overlapping or parallel as needed. Pederick et al. analyzed how parallel circuits in the mouse medial and lateral hippocampus develop without getting tangled up. Regulated expression of the cell surface molecules teneurin-3 (Ten3) and latrophilin-2 (Lphn2) keeps confusion at bay. Together, these factors act as a membrane-bound ligand-receptor pair with repulsive outcomes, and they are able to destabilize a nascent but incorrect axon-target interaction. Individually, they each mediate homophilic attraction as axons search for their favored targets. Science, abg1774, this issue p. [1068][1] Mammalian medial and lateral hippocampal networks preferentially process spatial- and object-related information, respectively. However, the mechanisms underlying the assembly of such parallel networks during development remain largely unknown. Our study shows that, in mice, complementary expression of cell surface molecules teneurin-3 (Ten3) and latrophilin-2 (Lphn2) in the medial and lateral hippocampal networks, respectively, guides the precise assembly of CA1-to-subiculum connections in both networks. In the medial network, Ten3-expressing (Ten3+) CA1 axons are repelled by target-derived Lphn2, revealing that Lphn2- and Ten3-mediated heterophilic repulsion and Ten3-mediated homophilic attraction cooperate to control precise target selection of CA1 axons. In the lateral network, Lphn2-expressing (Lphn2+) CA1 axons are confined to Lphn2+ targets via repulsion from Ten3+ targets. Our findings demonstrate that assembly of parallel hippocampal networks follows a “Ten3→Ten3, Lphn2→Lphn2” rule instructed by reciprocal repulsions. [1]: /lookup/doi/10.1126/science.abg1774
领域	气候变化 ; 资源环境
URL	查看原文
引用统计	被引频次：27[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/329870
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Daniel T. Pederick,Jan H. Lui,Ellen C. Gingrich,et al. Reciprocal repulsions instruct the precise assembly of parallel hippocampal networks[J]. Science,2021.
APA	Daniel T. Pederick.,Jan H. Lui.,Ellen C. Gingrich.,Chuanyun Xu.,Mark J. Wagner.,...&Liqun Luo.(2021).Reciprocal repulsions instruct the precise assembly of parallel hippocampal networks.Science.
MLA	Daniel T. Pederick,et al."Reciprocal repulsions instruct the precise assembly of parallel hippocampal networks".Science (2021).