Conserved genetic signatures parcellate cardinal spinal neuron classes into local and projection subsets

doi:10.1126/science.abe0690

GSTDTAP > 气候变化

DOI	10.1126/science.abe0690
	Conserved genetic signatures parcellate cardinal spinal neuron classes into local and projection subsets
	Peter J. Osseward; Neal D. Amin; Jeffrey D. Moore; Benjamin A. Temple; Bianca K. Barriga; Lukas C. Bachmann; Fernando Beltran; Miriam Gullo; Robert C. Clark; Shawn P. Driscoll; Samuel L. Pfaff; Marito Hayashi
	2021-04-23
发表期刊	Science
出版年	2021
英文摘要	Neurons of the mouse spinal cord can be identified by any of several metrics, including what neurotransmitters they use, what cells they connect to, where they are located, and what neuroprogenitor gave rise to them. Osseward et al. generated a different metric, genetic signatures, and identified classes of local and projection neurons that were otherwise heterogeneous by other classification systems. With this focus on a cell's genetic signature, its neurotransmitter phenotype, which is accessible by a variety of transcriptional routes, can be seen as a parallel to convergent evolution in development. Science , this issue p. [385][1] Motor and sensory functions of the spinal cord are mediated by populations of cardinal neurons arising from separate progenitor lineages. However, each cardinal class is composed of multiple neuronal types with distinct molecular, anatomical, and physiological features, and there is not a unifying logic that systematically accounts for this diversity. We reasoned that the expansion of new neuronal types occurred in a stepwise manner analogous to animal speciation, and we explored this by defining transcriptomic relationships using a top-down approach. We uncovered orderly genetic tiers that sequentially divide groups of neurons by their motor-sensory, local-long range, and excitatory-inhibitory features. The genetic signatures defining neuronal projections were tied to neuronal birth date and conserved across cardinal classes. Thus, the intersection of cardinal class with projection markers provides a unifying taxonomic solution for systematically identifying distinct functional subsets. [1]: /lookup/doi/10.1126/science.abe0690
领域	气候变化 ; 资源环境
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文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/324078
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Peter J. Osseward,Neal D. Amin,Jeffrey D. Moore,et al. Conserved genetic signatures parcellate cardinal spinal neuron classes into local and projection subsets[J]. Science,2021.
APA	Peter J. Osseward.,Neal D. Amin.,Jeffrey D. Moore.,Benjamin A. Temple.,Bianca K. Barriga.,...&Marito Hayashi.(2021).Conserved genetic signatures parcellate cardinal spinal neuron classes into local and projection subsets.Science.
MLA	Peter J. Osseward,et al."Conserved genetic signatures parcellate cardinal spinal neuron classes into local and projection subsets".Science (2021).