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DOI | 10.1289/EHP8368 |
Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality—a Pooled Analysis of Eight European Cohorts within the ELAPSE Project | |
Jie Chen; Sophia Rodopoulou; Kees de Hoogh; Maciej Strak; Zorana J. Andersen; Richard Atkinson; Mariska Bauwelinck; Tom Bellander; Jørgen Brandt; Giulia Cesaroni; Hans Concin; Daniela Fecht; Francesco Forastiere; John Gulliver; Ole Hertel; Barbara Hoffmann; Ulla Arthur Hvidtfeldt; Nicole A. H. Janssen; Karl-Heinz Jöckel; Jeanette Jørgensen; Klea Katsouyanni; Matthias Ketzel; Jochem O. Klompmaker; Anton Lager; Karin Leander; Shuo Liu; Petter Ljungman; Conor J. MacDonald; Patrik K.E. Magnusson; Amar Mehta; Gabriele Nagel; Bente Oftedal; Göran Pershagen; Annette Peters; Ole Raaschou-Nielsen; Matteo Renzi; Debora Rizzuto; Evangelia Samoli; Yvonne T. van der Schouw; Sara Schramm; Per Schwarze; Torben Sigsgaard; Mette Sørensen; Massimo Stafoggia; Anne Tjønneland; Danielle Vienneau; Gudrun Weinmayr; Kathrin Wolf; Bert Brunekreef; Gerard Hoek | |
2021-04-12 | |
发表期刊 | Environmental Health Perspectives |
出版年 | 2021 |
英文摘要 | AbstractBackground:Inconsistent associations between long-term exposure to particles with an aerodynamic diameter [fine particulate matter ()] components and mortality have been reported, partly related to challenges in exposure assessment. Objectives:We investigated the associations between long-term exposure to elemental components and mortality in a large pooled European cohort; to compare health effects of components estimated with two exposure modeling approaches, namely, supervised linear regression (SLR) and random forest (RF) algorithms. Methods:We pooled data from eight European cohorts with 323,782 participants, average age 49 y at baseline (1985–2005). Residential exposure to 2010 annual average concentration of eight components [copper (Cu), iron (Fe), potassium (K), nickel (Ni), sulfur (S), silicon (Si), vanadium (V), and zinc (Zn)] was estimated with Europe-wide SLR and RF models at a scale. We applied Cox proportional hazards models to investigate the associations between components and natural and cause-specific mortality. In addition, two-pollutant analyses were conducted by adjusting each component for mass and nitrogen dioxide () separately. Results:We observed 46,640 natural-cause deaths with 6,317,235 person-years and an average follow-up of 19.5 y. All SLR-modeled components were statistically significantly associated with natural-cause mortality in single-pollutant models with hazard ratios (HRs) from 1.05 to 1.27. Similar HRs were observed for RF-modeled Cu, Fe, K, S, V, and Zn with wider confidence intervals (CIs). HRs for SLR-modeled Ni, S, Si, V, and Zn remained above unity and (almost) significant after adjustment for both and . HRs only remained (almost) significant for RF-modeled K and V in two-pollutant models. The HRs for V were 1.03 (95% CI: 1.02, 1.05) and 1.06 (95% CI: 1.02, 1.10) for SLR- and RF-modeled exposures, respectively, per , adjusting for mass. Associations with cause-specific mortality were less consistent in two-pollutant models. Conclusion:Long-term exposure to V in was most consistently associated with increased mortality. Associations for the other components were weaker for exposure modeled with RF than SLR in two-pollutant models. https://doi.org/10.1289/EHP8368 |
领域 | 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/322764 |
专题 | 资源环境科学 |
推荐引用方式 GB/T 7714 | Jie Chen,Sophia Rodopoulou,Kees de Hoogh,et al. Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality—a Pooled Analysis of Eight European Cohorts within the ELAPSE Project[J]. Environmental Health Perspectives,2021. |
APA | Jie Chen.,Sophia Rodopoulou.,Kees de Hoogh.,Maciej Strak.,Zorana J. Andersen.,...&Gerard Hoek.(2021).Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality—a Pooled Analysis of Eight European Cohorts within the ELAPSE Project.Environmental Health Perspectives. |
MLA | Jie Chen,et al."Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality—a Pooled Analysis of Eight European Cohorts within the ELAPSE Project".Environmental Health Perspectives (2021). |
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