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DOI | 10.1126/science.abe2762 |
Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish | |
Masahito Ogawa; Fan-Suo Geng; David T. Humphreys; Esther Kristianto; Delicia Z. Sheng; Subhra P. Hui; Yuxi Zhang; Kotaro Sugimoto; Maki Nakayama; Dawei Zheng; Daniel Hesselson; Mark P. Hodson; Ozren Bogdanovic; Kazu Kikuchi | |
2021-04-09 | |
发表期刊 | Science
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出版年 | 2021 |
英文摘要 | Although humans show minimal regenerative capability, zebrafish can regenerate their hearts through a mechanism whereby heart muscle cells (cardiomyocytes) revert to a less mature state and then proliferate to replace the damaged tissue. Ogawa et al. show that Krüppel-like factor 1 (Klf1/Eklf), a transcription factor well known for its role in red blood cell development, is an essential factor for heart regeneration in zebrafish. Klf1 is specifically expressed in cardiomyocytes after injury, and its activation is sufficient to stimulate new cardiomyocyte production without injury. This potent effect is achieved through reprogramming of gene networks regulating cardiomyocyte differentiation and mitochondrial metabolism. Science , this issue p. [201][1] Cardiac regeneration requires dedifferentiation and proliferation of mature cardiomyocytes, but the mechanisms underlying this plasticity remain unclear. Here, we identify a potent cardiomyogenic role for Krüppel-like factor 1 (Klf1/Eklf), which is induced in adult zebrafish myocardium upon injury. Myocardial inhibition of Klf1 function does not affect heart development, but it severely impairs regeneration. Transient Klf1 activation is sufficient to expand mature myocardium in uninjured hearts. Klf1 directs epigenetic reprogramming of the cardiac transcription factor network, permitting coordinated cardiomyocyte dedifferentiation and proliferation. Myocardial expansion is supported by Klf1-induced rewiring of mitochondrial metabolism from oxidative respiration to anabolic pathways. Our findings establish Klf1 as a core transcriptional regulator of cardiomyocyte renewal in adult zebrafish hearts. [1]: /lookup/doi/10.1126/science.abe2762 |
领域 | 气候变化 ; 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/322101 |
专题 | 气候变化 资源环境科学 |
推荐引用方式 GB/T 7714 | Masahito Ogawa,Fan-Suo Geng,David T. Humphreys,et al. Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish[J]. Science,2021. |
APA | Masahito Ogawa.,Fan-Suo Geng.,David T. Humphreys.,Esther Kristianto.,Delicia Z. Sheng.,...&Kazu Kikuchi.(2021).Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish.Science. |
MLA | Masahito Ogawa,et al."Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish".Science (2021). |
条目包含的文件 | 条目无相关文件。 |
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