Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape

doi:10.1126/science.abf6950

GSTDTAP > 气候变化

DOI	10.1126/science.abf6950
	Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape
	Kevin R. McCarthy; Linda J. Rennick; Sham Nambulli; Lindsey R. Robinson-McCarthy; William G. Bain; Ghady Haidar; W. Paul Duprex
	2021-03-12
发表期刊	Science
出版年	2021
英文摘要	Influenza viruses evade immunity initiated by previous infection, which explains recurrent influenza pandemics. Unlike the error-prone RNA-dependent RNA polymerase of influenza, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and related viruses contain polymerases with proofreading activity. However, proofreading cannot correct deletions, which during a long-term persistent infection could result in the generation of viruses showing alteration of entire stretches of amino acids and the structures they form. McCarthy et al. identified an evolutionary signature defined by prevalent and recurrent deletions in the spike protein of SARS-CoV-2 at four antigenic sites. Deletion variants show human-to-human transmission of viruses with altered antigenicity. Science , this issue p. [1139][1] Zoonotic pandemics, such as that caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can follow the spillover of animal viruses into highly susceptible human populations. The descendants of these viruses have adapted to the human host and evolved to evade immune pressure. Coronaviruses acquire substitutions more slowly than other RNA viruses. In the spike glycoprotein, we found that recurrent deletions overcome this slow substitution rate. Deletion variants arise in diverse genetic and geographic backgrounds, transmit efficiently, and are present in novel lineages, including those of current global concern. They frequently occupy recurrent deletion regions (RDRs), which map to defined antibody epitopes. Deletions in RDRs confer resistance to neutralizing antibodies. By altering stretches of amino acids, deletions appear to accelerate SARS-CoV-2 antigenic evolution and may, more generally, drive adaptive evolution. [1]: /lookup/doi/10.1126/science.abf6950
领域	气候变化 ; 资源环境
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文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/318692
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Kevin R. McCarthy,Linda J. Rennick,Sham Nambulli,et al. Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape[J]. Science,2021.
APA	Kevin R. McCarthy.,Linda J. Rennick.,Sham Nambulli.,Lindsey R. Robinson-McCarthy.,William G. Bain.,...&W. Paul Duprex.(2021).Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape.Science.
MLA	Kevin R. McCarthy,et al."Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape".Science (2021).