Prospective mapping of viral mutations that escape antibodies used to treat COVID-19

doi:10.1126/science.abf9302

GSTDTAP > 气候变化

DOI	10.1126/science.abf9302
	Prospective mapping of viral mutations that escape antibodies used to treat COVID-19
	Tyler N. Starr; Allison J. Greaney; Amin Addetia; William W. Hannon; Manish C. Choudhary; Adam S. Dingens; Jonathan Z. Li; Jesse D. Bloom
	2021-02-19
发表期刊	Science
出版年	2021
英文摘要	Several antibodies are in use or under development as therapies to treat COVID-19. As new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants emerge, it is important to predict whether they will remain susceptible to antibody treatment. Starr et al. used a yeast library that covers all mutations to the SARS-CoV-2 receptor-binding domain that do not strongly disrupt binding to the host receptor (ACE2) and mapped how these mutations affect binding to three leading anti–SARS-CoV-2 antibodies. The maps identify mutations that escape antibody binding, including a single mutation that escapes both antibodies in the Regeneron antibody cocktail. Many of the mutations that escape single antibodies are circulating in the human population. Science , this issue p. [850][1] Antibodies are a potential therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the risk of the virus evolving to escape them remains unclear. Here we map how all mutations to the receptor binding domain (RBD) of SARS-CoV-2 affect binding by the antibodies in the REGN-COV2 cocktail and the antibody LY-CoV016. These complete maps uncover a single amino acid mutation that fully escapes the REGN-COV2 cocktail, which consists of two antibodies, REGN10933 and REGN10987, targeting distinct structural epitopes. The maps also identify viral mutations that are selected in a persistently infected patient treated with REGN-COV2 and during in vitro viral escape selections. Finally, the maps reveal that mutations escaping the individual antibodies are already present in circulating SARS-CoV-2 strains. These complete escape maps enable interpretation of the consequences of mutations observed during viral surveillance. [1]: /lookup/doi/10.1126/science.abf9302
领域	气候变化 ; 资源环境
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/315733
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Tyler N. Starr,Allison J. Greaney,Amin Addetia,et al. Prospective mapping of viral mutations that escape antibodies used to treat COVID-19[J]. Science,2021.
APA	Tyler N. Starr.,Allison J. Greaney.,Amin Addetia.,William W. Hannon.,Manish C. Choudhary.,...&Jesse D. Bloom.(2021).Prospective mapping of viral mutations that escape antibodies used to treat COVID-19.Science.
MLA	Tyler N. Starr,et al."Prospective mapping of viral mutations that escape antibodies used to treat COVID-19".Science (2021).