MAIT cell activation augments adenovirus vector vaccine immunogenicity

doi:10.1126/science.aax8819

GSTDTAP > 气候变化

DOI	10.1126/science.aax8819
	MAIT cell activation augments adenovirus vector vaccine immunogenicity
	Nicholas M. Provine; Ali Amini; Lucy C. Garner; Alexandra J. Spencer; Christina Dold; Claire Hutchings; Laura Silva Reyes; Michael E. B. FitzPatrick; Senthil Chinnakannan; Blanche Oguti; Meriel Raymond; Marta Ulaszewska; Fulvia Troise; Hannah Sharpe; Sophie B. Morgan; Timothy S. C. Hinks; Teresa Lambe; Stefania Capone; Antonella Folgori; Eleanor Barnes; Christine S. Rollier; Andrew J. Pollard; Paul Klenerman
	2021-01-29
发表期刊	Science
出版年	2021
英文摘要	Mucosal-associated invariant T (MAIT) cells are a T cell subset important for mucosal homeostasis. These cells recognize derivatives of microbiota-derived vitamin B2 precursors but can also be activated by certain cytokines in the context of viral infections. Provine et al. report that a leading adenoviral vector vaccine, ChAdOx1, activated MAIT cells in immunized mice (see the Perspective by Juno and O'Connor). This activation required interferon-α produced by plasmacytoid dendritic cells as well as monocyte-derived interleukin-18 and tumor necrosis factor. MAIT cell activation positively correlated with vaccine-mediated T cell responses in human subjects, and mice deficient in MAIT cells showed impaired CD8+ T cell immunity to target antigens after vaccination. This work suggests an additional pathway that could be exploited to enhance the efficacy of vaccines. Science , this issue p. [521][1]; see also p. [460][2] Mucosal-associated invariant T (MAIT) cells are innate sensors of viruses and can augment early immune responses and contribute to protection. We hypothesized that MAIT cells may have inherent adjuvant activity in vaccine platforms that use replication-incompetent adenovirus vectors. In mice and humans, ChAdOx1 (chimpanzee adenovirus Ox1) immunization robustly activated MAIT cells. Activation required plasmacytoid dendritic cell (pDC)–derived interferon (IFN)–α and monocyte-derived interleukin-18. IFN-α–induced, monocyte-derived tumor necrosis factor was also identified as a key secondary signal. All three cytokines were required in vitro and in vivo. Activation of MAIT cells positively correlated with vaccine-induced T cell responses in human volunteers and MAIT cell–deficient mice displayed impaired CD8+ T cell responses to multiple vaccine-encoded antigens. Thus, MAIT cells contribute to the immunogenicity of adenovirus vectors, with implications for vaccine design. [1]: /lookup/doi/10.1126/science.aax8819 [2]: /lookup/doi/10.1126/science.abf8121
领域	气候变化 ; 资源环境
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文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/314019
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Nicholas M. Provine,Ali Amini,Lucy C. Garner,et al. MAIT cell activation augments adenovirus vector vaccine immunogenicity[J]. Science,2021.
APA	Nicholas M. Provine.,Ali Amini.,Lucy C. Garner.,Alexandra J. Spencer.,Christina Dold.,...&Paul Klenerman.(2021).MAIT cell activation augments adenovirus vector vaccine immunogenicity.Science.
MLA	Nicholas M. Provine,et al."MAIT cell activation augments adenovirus vector vaccine immunogenicity".Science (2021).