Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1111/ele.12726 |
A framework for how environment contributes to cancer risk | |
Hochberg, Michael E.1,2; Noble, Robert J.1 | |
2017-02-01 | |
发表期刊 | ECOLOGY LETTERS |
ISSN | 1461-023X |
EISSN | 1461-0248 |
出版年 | 2017 |
卷号 | 20期号:2 |
文章类型 | Article |
语种 | 英语 |
国家 | France; USA |
英文摘要 | Evolutionary theory explains why metazoan species are largely protected against the negative fitness effects of cancers. Nevertheless, cancer is often observed at high incidence across a range of species. Although there are many challenges to quantifying cancer epidemiology and assessing its causes, we claim that most modern-day cancer in animals - and humans in particular - are due to environments deviating from central tendencies of distributions that have prevailed during cancer resistance evolution. Such novel environmental conditions may be natural and/or of anthropogenic origin, and may interface with cancer risk in numerous ways, broadly classifiable as those: increasing organism body size and/or life span, disrupting processes within the organism, and affecting germline. We argue that anthropogenic influences, in particular, explain much of the present-day cancer risk across life, including in humans. Based on a literature survey of animal species and a parameterised mathematical model for humans, we suggest that combined risks of all cancers in a population beyond c. 5% can be explained to some extent by the influence of novel environments. Our framework provides a basis for understanding how natural environmental variation and human activity impact cancer risk, with potential implications for species ecology. |
英文关键词 | Ageing anthropogenic impact body size cancer risk environment epidemiology evolutionary mismatch global change longevity modern lifestyles mutagens pathogens |
领域 | 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000395173300001 |
WOS关键词 | LIFE-STYLE ; EVOLUTIONARY DYNAMICS ; UNITED-STATES ; HUMAN-PAPILLOMAVIRUS ; CELLULAR SENESCENCE ; NEOPLASTIC DISEASES ; POPULATION-GENETICS ; NICHE CONSTRUCTION ; HEMOCYTIC LEUKEMIA ; POSITIVE SELECTION |
WOS类目 | Ecology |
WOS研究方向 | Environmental Sciences & Ecology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/31382 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Montpellier, Intstitut Sci Evolut Montpellier, Pl E Bataillon,CC065, F-34095 Montpellier 5, France; 2.Santa Fe Inst, 1399 Hyde Pk Rd, Santa Fe, NM 87501 USA |
推荐引用方式 GB/T 7714 | Hochberg, Michael E.,Noble, Robert J.. A framework for how environment contributes to cancer risk[J]. ECOLOGY LETTERS,2017,20(2). |
APA | Hochberg, Michael E.,&Noble, Robert J..(2017).A framework for how environment contributes to cancer risk.ECOLOGY LETTERS,20(2). |
MLA | Hochberg, Michael E.,et al."A framework for how environment contributes to cancer risk".ECOLOGY LETTERS 20.2(2017). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论