Clock genes and environmental cues coordinate <em>Anopheles</em> pheromone synthesis, swarming, and mating

doi:10.1126/science.abd4359

GSTDTAP > 气候变化

DOI	10.1126/science.abd4359
	*Clock genes and environmental cues coordinate Anopheles* pheromone synthesis, swarming, and mating**
	Guandong Wang; Joel Vega-Rodríguez; Abdoulaye Diabate; Jingnan Liu; Chunlai Cui; Charles Nignan; Ling Dong; Fang Li; Cheick Oumar Ouedrago; Abdoul Malik Bandaogo; Péguédwindé Simon Sawadogo; Hamidou Maiga; Thiago Luiz Alves e Silva; Tales Vicari Pascini; Sibao Wang; Marcelo Jacobs-Lorena
	2021-01-22
发表期刊	Science
出版年	2021
英文摘要	Several species of anopheline mosquitoes are important malaria vectors in Africa. Male mosquitoes show species-specific swarming behaviors at certain times of the day to attract females for mating. Wang et al. found that transcriptional patterns of metabolic and immune function genes apparently showed a diurnal rhythm that correlated with the physiological demands of mating flight swarming (see the Perspective by Manoukis). By altering temperature and light regimes and by knocking out the master genes period and timeless for circadian clock regulation, the authors disrupted mating flight behavior in a combination of cage experiments and enclosed field conditions. Knocking out the rhythmically expressed desaturase enzyme reduced cuticular hydrocarbon pheromone production and limited mating success. These key interacting components of the diurnal regulation of mosquito mating behavior are potential targets for alternative malaria control strategies. Science , this issue p. [411][1]; see also p. [340][2] Anopheles mating is initiated by the swarming of males at dusk followed by females flying into the swarm. Here, we show that mosquito swarming and mating are coordinately guided by clock genes, light, and temperature. Transcriptome analysis shows up-regulation of the clock genes period ( per ) and timeless ( tim ) in the head of field-caught swarming Anopheles coluzzii males. Knockdown of per and tim expression affects Anopheles gambiae s.s. and Anopheles stephensi male mating in the laboratory, and it reduces male An. coluzzii swarming and mating under semifield conditions. Light and temperature affect mosquito mating, possibly by modulating per and/or tim expression. Moreover, the desaturase gene desat1 is up-regulated and rhythmically expressed in the heads of swarming males and regulates the production of cuticular hydrocarbons, including heptacosane, which stimulates mating activity. [1]: /lookup/doi/10.1126/science.abd4359 [2]: /lookup/doi/10.1126/science.abf7917
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/312370
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Guandong Wang,Joel Vega-Rodríguez,Abdoulaye Diabate,et al. Clock genes and environmental cues coordinate Anopheles pheromone synthesis, swarming, and mating[J]. Science,2021.
APA	Guandong Wang.,Joel Vega-Rodríguez.,Abdoulaye Diabate.,Jingnan Liu.,Chunlai Cui.,...&Marcelo Jacobs-Lorena.(2021).Clock genes and environmental cues coordinate Anopheles pheromone synthesis, swarming, and mating.Science.
MLA	Guandong Wang,et al."Clock genes and environmental cues coordinate Anopheles pheromone synthesis, swarming, and mating".Science (2021).