Host succinate is an activation signal for <em>Salmonella</em> virulence during intracellular infection

doi:10.1126/science.aba8026

GSTDTAP > 气候变化

DOI	10.1126/science.aba8026
	*Host succinate is an activation signal for Salmonella* virulence during intracellular infection**
	Gili Rosenberg; Dror Yehezkel; Dotan Hoffman; Camilla Ciolli Mattioli; Moran Fremder; Hadar Ben-Arosh; Leia Vainman; Noa Nissani; Shelly Hen-Avivi; Shirley Brenner; Maxim Itkin; Sergey Malitsky; Ehud Ohana; Noa Bossel Ben-Moshe; Roi Avraham
	2021-01-22
发表期刊	Science
出版年	2021
英文摘要	Extensive metabolic rewiring occurs in various immune cells during the course of infection. Whether these changes can be exploited by intracellular pathogens remains an open question. Rosenberg et al. report that infection with Salmonella enterica serovar Typhimurium ( S. Tm) induces the accumulation of the metabolite succinate in macrophages (see the Perspective by Lynch and Lesser). This key intermediate in the citric acid cycle activates virulence genes in S. Tm, leading to microbial resistance. Moreover, the active transport of succinate through the C4-dicarboxylate transporter DcuB is required for S. Tm virulence and survival within macrophages. Sensing of citric acid cycle intermediates may more generally serve as a cue to initiate the resistance programs of intracellular pathogens. Science , this issue p. [400][1]; see also p. [344][2] Key to the success of intracellular pathogens is the ability to sense and respond to a changing host cell environment. Macrophages exposed to microbial products undergo metabolic changes that drive inflammatory responses. However, the role of macrophage metabolic reprogramming in bacterial adaptation to the intracellular environment has not been explored. Here, using metabolic profiling and dual RNA sequencing, we show that succinate accumulation in macrophages is sensed by intracellular Salmonella Typhimurium ( S. Tm) to promote antimicrobial resistance and type III secretion. S . Tm lacking the succinate uptake transporter DcuB displays impaired survival in macrophages and in mice. Thus, S . Tm co-opts the metabolic reprogramming of infected macrophages as a signal that induces its own virulence and survival, providing an additional perspective on metabolic host–pathogen cross-talk. [1]: /lookup/doi/10.1126/science.aba8026 [2]: /lookup/doi/10.1126/science.abf8414
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/312368
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Gili Rosenberg,Dror Yehezkel,Dotan Hoffman,et al. Host succinate is an activation signal for Salmonella virulence during intracellular infection[J]. Science,2021.
APA	Gili Rosenberg.,Dror Yehezkel.,Dotan Hoffman.,Camilla Ciolli Mattioli.,Moran Fremder.,...&Roi Avraham.(2021).Host succinate is an activation signal for Salmonella virulence during intracellular infection.Science.
MLA	Gili Rosenberg,et al."Host succinate is an activation signal for Salmonella virulence during intracellular infection".Science (2021).