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DOI | 10.1126/science.abe4713 |
Controlled hydroxylations of diterpenoids allow for plant chemical defense without autotoxicity | |
Jiancai Li; Rayko Halitschke; Dapeng Li; Christian Paetz; Haichao Su; Sven Heiling; Shuqing Xu; Ian T. Baldwin | |
2021-01-15 | |
发表期刊 | Science
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出版年 | 2021 |
英文摘要 | Plants make a variety of molecules that serve to protect them against hungry insects. Li et al. analyzed the balance between plants defending themselves and plants poisoning themselves. In wild tobacco ( Nicotiana attenuata ), two cytochrome P450 enzymes work within the biosynthetic pathway of 17-hydroxygeranyllinalool diterpene glycosides to help prevent the accumulation of toxic diterpene derivatives. Those same diterpene derivatives are formed in an insect herbivore after ingestion and cause toxicity by inhibiting sphingolipid biosynthesis in both plant and insect. Science , this issue p. [255][1] Many plant specialized metabolites function in herbivore defense, and abrogating particular steps in their biosynthetic pathways frequently causes autotoxicity. However, the molecular mechanisms underlying their defense and autotoxicity remain unclear. Here, we show that silencing two cytochrome P450s involved in diterpene biosynthesis in the wild tobacco Nicotiana attenuata causes severe autotoxicity symptoms that result from the inhibition of sphingolipid biosynthesis by noncontrolled hydroxylated diterpene derivatives. Moreover, the diterpenes’ defensive function is achieved by inhibiting herbivore sphingolipid biosynthesis through postingestive backbone hydroxylation products. Thus, by regulating metabolic modifications, tobacco plants avoid autotoxicity and gain herbivore defense. The postdigestive duet that occurs between plants and their insect herbivores can reflect the plant’s solutions to the “toxic waste dump” problem of using potent chemical defenses. [1]: /lookup/doi/10.1126/science.abe4713 |
领域 | 气候变化 ; 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/311491 |
专题 | 气候变化 资源环境科学 |
推荐引用方式 GB/T 7714 | Jiancai Li,Rayko Halitschke,Dapeng Li,et al. Controlled hydroxylations of diterpenoids allow for plant chemical defense without autotoxicity[J]. Science,2021. |
APA | Jiancai Li.,Rayko Halitschke.,Dapeng Li.,Christian Paetz.,Haichao Su.,...&Ian T. Baldwin.(2021).Controlled hydroxylations of diterpenoids allow for plant chemical defense without autotoxicity.Science. |
MLA | Jiancai Li,et al."Controlled hydroxylations of diterpenoids allow for plant chemical defense without autotoxicity".Science (2021). |
条目包含的文件 | 条目无相关文件。 |
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