Controlled hydroxylations of diterpenoids allow for plant chemical defense without autotoxicity

doi:10.1126/science.abe4713

GSTDTAP > 气候变化

DOI	10.1126/science.abe4713
	Controlled hydroxylations of diterpenoids allow for plant chemical defense without autotoxicity
	Jiancai Li; Rayko Halitschke; Dapeng Li; Christian Paetz; Haichao Su; Sven Heiling; Shuqing Xu; Ian T. Baldwin
	2021-01-15
发表期刊	Science
出版年	2021
英文摘要	Plants make a variety of molecules that serve to protect them against hungry insects. Li et al. analyzed the balance between plants defending themselves and plants poisoning themselves. In wild tobacco ( Nicotiana attenuata ), two cytochrome P450 enzymes work within the biosynthetic pathway of 17-hydroxygeranyllinalool diterpene glycosides to help prevent the accumulation of toxic diterpene derivatives. Those same diterpene derivatives are formed in an insect herbivore after ingestion and cause toxicity by inhibiting sphingolipid biosynthesis in both plant and insect. Science , this issue p. [255][1] Many plant specialized metabolites function in herbivore defense, and abrogating particular steps in their biosynthetic pathways frequently causes autotoxicity. However, the molecular mechanisms underlying their defense and autotoxicity remain unclear. Here, we show that silencing two cytochrome P450s involved in diterpene biosynthesis in the wild tobacco Nicotiana attenuata causes severe autotoxicity symptoms that result from the inhibition of sphingolipid biosynthesis by noncontrolled hydroxylated diterpene derivatives. Moreover, the diterpenes’ defensive function is achieved by inhibiting herbivore sphingolipid biosynthesis through postingestive backbone hydroxylation products. Thus, by regulating metabolic modifications, tobacco plants avoid autotoxicity and gain herbivore defense. The postdigestive duet that occurs between plants and their insect herbivores can reflect the plant’s solutions to the “toxic waste dump” problem of using potent chemical defenses. [1]: /lookup/doi/10.1126/science.abe4713
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/311491
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Jiancai Li,Rayko Halitschke,Dapeng Li,et al. Controlled hydroxylations of diterpenoids allow for plant chemical defense without autotoxicity[J]. Science,2021.
APA	Jiancai Li.,Rayko Halitschke.,Dapeng Li.,Christian Paetz.,Haichao Su.,...&Ian T. Baldwin.(2021).Controlled hydroxylations of diterpenoids allow for plant chemical defense without autotoxicity.Science.
MLA	Jiancai Li,et al."Controlled hydroxylations of diterpenoids allow for plant chemical defense without autotoxicity".Science (2021).