Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1111/ele.12919 |
Competing for blood: the ecology of parasite resource competition in human malaria-helminth co-infections | |
Budischak, Sarah A.1; Wiria, Aprilianto E.2,3; Hamid, Firdaus2,4; Wammes, Linda J.2,5; Kaisar, Maria M. M.2,3; van Lieshout, Lisette2; Sartono, Erliyani2; Supali, Taniawati3; Yazdanbakhsh, Maria2; Graham, Andrea L.1 | |
2018-04-01 | |
发表期刊 | ECOLOGY LETTERS
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ISSN | 1461-023X |
EISSN | 1461-0248 |
出版年 | 2018 |
卷号 | 21期号:4页码:536-545 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Netherlands; Indonesia |
英文摘要 | Ecological theory suggests that co-infecting parasite species can interact within hosts directly, via host immunity and/or via resource competition. In mice, competition for red blood cells (RBCs) between malaria and bloodsucking helminths can regulate malaria population dynamics, but the importance of RBC competition in human hosts was unknown. We analysed infection density (i.e. the concentration of parasites in infected hosts), from a 2-year deworming study of over 4000 human subjects. After accounting for resource-use differences among parasites, we find evidence of resource competition, priority effects and a competitive hierarchy within co-infected individuals. For example reducing competition via deworming increased Plasmodium vivax densities 2.8-fold, and this effect is limited to bloodsucking hookworms. Our ecological, resource-based perspective sheds new light into decades of conflicting outcomes of malaria-helminth co-infection studies with significant health and transmission consequences. Beyond blood, investigating within-human resource competition may bring new insights for improving human health. |
英文关键词 | Ascaris lumbricoides co-infection interactions Hookworms Plasmodium falciparum Plasmodium vivax resource competition within-host ecology |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000427007400007 |
WOS关键词 | REAL-TIME PCR ; HOOKWORM INFECTION ; METAANALYSIS ; COMMUNITIES ; FALCIPARUM ; POPULATION ; DIAGNOSIS ; MOSQUITOS ; NEMATODES ; CHILDREN |
WOS类目 | Ecology |
WOS研究方向 | Environmental Sciences & Ecology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/31133 |
专题 | 资源环境科学 |
作者单位 | 1.Princeton Univ, Dept Ecol & Evolut Biol, Princeton, NJ 08544 USA; 2.Leiden Univ, Med Ctr, Dept Parasitol, Leiden, Netherlands; 3.Univ Indonesia, Fac Med, Dept Parasitol, Jakarta, Indonesia; 4.Hasanuddin Univ, Fac Med, Dept Microbiol, Makassar, Indonesia; 5.Erasmus MC, Dept Med Microbiol, Rotterdam, Netherlands |
推荐引用方式 GB/T 7714 | Budischak, Sarah A.,Wiria, Aprilianto E.,Hamid, Firdaus,et al. Competing for blood: the ecology of parasite resource competition in human malaria-helminth co-infections[J]. ECOLOGY LETTERS,2018,21(4):536-545. |
APA | Budischak, Sarah A..,Wiria, Aprilianto E..,Hamid, Firdaus.,Wammes, Linda J..,Kaisar, Maria M. M..,...&Graham, Andrea L..(2018).Competing for blood: the ecology of parasite resource competition in human malaria-helminth co-infections.ECOLOGY LETTERS,21(4),536-545. |
MLA | Budischak, Sarah A.,et al."Competing for blood: the ecology of parasite resource competition in human malaria-helminth co-infections".ECOLOGY LETTERS 21.4(2018):536-545. |
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