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DOI10.1111/ele.12919
Competing for blood: the ecology of parasite resource competition in human malaria-helminth co-infections
Budischak, Sarah A.1; Wiria, Aprilianto E.2,3; Hamid, Firdaus2,4; Wammes, Linda J.2,5; Kaisar, Maria M. M.2,3; van Lieshout, Lisette2; Sartono, Erliyani2; Supali, Taniawati3; Yazdanbakhsh, Maria2; Graham, Andrea L.1
2018-04-01
发表期刊ECOLOGY LETTERS
ISSN1461-023X
EISSN1461-0248
出版年2018
卷号21期号:4页码:536-545
文章类型Article
语种英语
国家USA; Netherlands; Indonesia
英文摘要

Ecological theory suggests that co-infecting parasite species can interact within hosts directly, via host immunity and/or via resource competition. In mice, competition for red blood cells (RBCs) between malaria and bloodsucking helminths can regulate malaria population dynamics, but the importance of RBC competition in human hosts was unknown. We analysed infection density (i.e. the concentration of parasites in infected hosts), from a 2-year deworming study of over 4000 human subjects. After accounting for resource-use differences among parasites, we find evidence of resource competition, priority effects and a competitive hierarchy within co-infected individuals. For example reducing competition via deworming increased Plasmodium vivax densities 2.8-fold, and this effect is limited to bloodsucking hookworms. Our ecological, resource-based perspective sheds new light into decades of conflicting outcomes of malaria-helminth co-infection studies with significant health and transmission consequences. Beyond blood, investigating within-human resource competition may bring new insights for improving human health.


英文关键词Ascaris lumbricoides co-infection interactions Hookworms Plasmodium falciparum Plasmodium vivax resource competition within-host ecology
领域资源环境
收录类别SCI-E
WOS记录号WOS:000427007400007
WOS关键词REAL-TIME PCR ; HOOKWORM INFECTION ; METAANALYSIS ; COMMUNITIES ; FALCIPARUM ; POPULATION ; DIAGNOSIS ; MOSQUITOS ; NEMATODES ; CHILDREN
WOS类目Ecology
WOS研究方向Environmental Sciences & Ecology
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/31133
专题资源环境科学
作者单位1.Princeton Univ, Dept Ecol & Evolut Biol, Princeton, NJ 08544 USA;
2.Leiden Univ, Med Ctr, Dept Parasitol, Leiden, Netherlands;
3.Univ Indonesia, Fac Med, Dept Parasitol, Jakarta, Indonesia;
4.Hasanuddin Univ, Fac Med, Dept Microbiol, Makassar, Indonesia;
5.Erasmus MC, Dept Med Microbiol, Rotterdam, Netherlands
推荐引用方式
GB/T 7714
Budischak, Sarah A.,Wiria, Aprilianto E.,Hamid, Firdaus,et al. Competing for blood: the ecology of parasite resource competition in human malaria-helminth co-infections[J]. ECOLOGY LETTERS,2018,21(4):536-545.
APA Budischak, Sarah A..,Wiria, Aprilianto E..,Hamid, Firdaus.,Wammes, Linda J..,Kaisar, Maria M. M..,...&Graham, Andrea L..(2018).Competing for blood: the ecology of parasite resource competition in human malaria-helminth co-infections.ECOLOGY LETTERS,21(4),536-545.
MLA Budischak, Sarah A.,et al."Competing for blood: the ecology of parasite resource competition in human malaria-helminth co-infections".ECOLOGY LETTERS 21.4(2018):536-545.
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