Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP7215 |
Community Approaches for Integrating Environmental Exposures into Human Models of Disease | |
Anne E. Thessen; Cynthia J. Grondin; Resham D. Kulkarni; Susanne Brander; Lisa Truong; Nicole A. Vasilevsky; Tiffany J. Callahan; Lauren E. Chan; Brian Westra; Mary Willis; Sarah E. Rothenberg; Annie M. Jarabek; Lyle Burgoon; Susan A. Korrick; Melissa A. Haendel | |
2020-12-28 | |
发表期刊 | Environmental Health Perspectives |
出版年 | 2020 |
英文摘要 | AbstractBackground:A critical challenge in genomic medicine is identifying the genetic and environmental risk factors for disease. Currently, the available data links a majority of known coding human genes to phenotypes, but the environmental component of human disease is extremely underrepresented in these linked data sets. Without environmental exposure information, our ability to realize precision health is limited, even with the promise of modern genomics. Achieving integration of gene, phenotype, and environment will require extensive translation of data into a standard, computable form and the extension of the existing gene/phenotype data model. The data standards and models needed to achieve this integration do not currently exist. Objectives:Our objective is to foster development of community-driven data-reporting standards and a computational model that will facilitate the inclusion of exposure data in computational analysis of human disease. To this end, we present a preliminary semantic data model and use cases and competency questions for further community-driven model development and refinement. Discussion:There is a real desire by the exposure science, epidemiology, and toxicology communities to use informatics approaches to improve their research workflow, gain new insights, and increase data reuse. Critical to success is the development of a community-driven data model for describing environmental exposures and linking them to existing models of human disease. https://doi.org/10.1289/EHP7215 |
领域 | 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/310356 |
专题 | 资源环境科学 |
推荐引用方式 GB/T 7714 | Anne E. Thessen,Cynthia J. Grondin,Resham D. Kulkarni,et al. Community Approaches for Integrating Environmental Exposures into Human Models of Disease[J]. Environmental Health Perspectives,2020. |
APA | Anne E. Thessen.,Cynthia J. Grondin.,Resham D. Kulkarni.,Susanne Brander.,Lisa Truong.,...&Melissa A. Haendel.(2020).Community Approaches for Integrating Environmental Exposures into Human Models of Disease.Environmental Health Perspectives. |
MLA | Anne E. Thessen,et al."Community Approaches for Integrating Environmental Exposures into Human Models of Disease".Environmental Health Perspectives (2020). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论