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What The Article Says: This Viewpoint discusses the need for scientific rigor in studies related to COVID-19 and presents study design recommendations and methodologies that should be incorporated to ensure that findings are reliable and reproducible.

Authors: Yu Shyr, Ph.D., of Vanderbilt University Medical Center in Nashville, Tennessee, is the corresponding author.

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(doi:10.1001/jamaoncol.2020.6639)

Editor's Note: The article includes conflict of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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