Robust neutralizing antibodies to SARS-CoV-2 infection persist for months

doi:10.1126/science.abd7728

GSTDTAP > 气候变化

DOI	10.1126/science.abd7728
	Robust neutralizing antibodies to SARS-CoV-2 infection persist for months
	Ania Wajnberg; Fatima Amanat; Adolfo Firpo; Deena R. Altman; Mark J. Bailey; Mayce Mansour; Meagan McMahon; Philip Meade; Damodara Rao Mendu; Kimberly Muellers; Daniel Stadlbauer; Kimberly Stone; Shirin Strohmeier; Viviana Simon; Judith Aberg; David L. Reich; Florian Krammer; Carlos Cordon-Cardo
	2020-12-04
发表期刊	Science
出版年	2020
英文摘要	As the number of daily COVID-19 cases continues to mount worldwide, the nature of the humoral immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains uncertain. Wajnberg et al. used a cohort of more than 30,000 infected individuals with mild to moderate COVID-19 symptoms to determine the robustness and longevity of the anti–SARS-CoV-2 antibody response. They found that neutralizing antibody titers against the SARS-CoV-2 spike protein persisted for at least 5 months after infection. Although continued monitoring of this cohort will be needed to confirm the longevity and potency of this response, these preliminary results suggest that the chance of reinfection may be lower than is currently feared. Science , this issue p. [1227][1] Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic with millions infected and more than 1 million fatalities. Questions regarding the robustness, functionality, and longevity of the antibody response to the virus remain unanswered. Here, on the basis of a dataset of 30,082 individuals screened at Mount Sinai Health System in New York City, we report that the vast majority of infected individuals with mild-to-moderate COVID-19 experience robust immunoglobulin G antibody responses against the viral spike protein. We also show that titers are relatively stable for at least a period of about 5 months and that anti-spike binding titers significantly correlate with neutralization of authentic SARS-CoV-2. Our data suggest that more than 90% of seroconverters make detectable neutralizing antibody responses. These titers remain relatively stable for several months after infection. [1]: /lookup/doi/10.1126/science.abd7728
领域	气候变化 ; 资源环境
URL	查看原文
引用统计	被引频次：788[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/305842
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Ania Wajnberg,Fatima Amanat,Adolfo Firpo,et al. Robust neutralizing antibodies to SARS-CoV-2 infection persist for months[J]. Science,2020.
APA	Ania Wajnberg.,Fatima Amanat.,Adolfo Firpo.,Deena R. Altman.,Mark J. Bailey.,...&Carlos Cordon-Cardo.(2020).Robust neutralizing antibodies to SARS-CoV-2 infection persist for months.Science.
MLA	Ania Wajnberg,et al."Robust neutralizing antibodies to SARS-CoV-2 infection persist for months".Science (2020).