Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.5194/acp-17-1381-2017 |
Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells | |
Mendoza, Alejandra1; Fang, Victoria1; Chen, Cynthia1; Serasinghe, Madhavika2; Verma, Akanksha3; Muller, James1; Chaluvadi, V. Sai1; Dustin, Michael L.1,4; Hla, Timothy5; Elemento, Olivier3; Chipuk, Jerry E.2; Schwab, Susan R.1 | |
2017-06-01 | |
发表期刊 | NATURE
![]() |
ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2017 |
卷号 | 546期号:7656页码:158-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; England |
英文摘要 | Effective adaptive immune responses require a large repertoire of naive T cells that migrate throughout the body, rapidly identifying almost any foreign peptide(1). Because the production of T cells declines with age, naive T cells must be long-lived(2). However, it remains unclear how naive T cells survive for years while constantly travelling. The chemoattractant sphingosine 1-phosphate (S1P) guides T cell circulation among secondary lymphoid organs, including spleen, lymph nodes and Peyer's patches, where T cells search for antigens. The concentration of S1P is higher in circulatory fluids than in lymphoid organs, and the S1P(1) receptor (S1P(1)R) directs the exit of T cells from the spleen into blood, and from lymph nodes and Peyer's patches into lymph(3). Here we show that S1P is essential not only for the circulation of naive T cells, but also for their survival. Using transgenic mouse models, we demonstrate that lymphatic endothelial cells support the survival of T cells by secreting S1P via the transporter SPNS2, that this S1P signals through S1P(1)R on T cells, and that the requirement for S1P(1)R is independent of the established role of the receptor in guiding exit from lymph nodes. S1P signalling maintains the mitochondrial content of naive T cells, providing cells with the energy to continue their constant migration. The S1P signalling pathway is being targeted therapeutically to inhibit autoreactive T cell trafficking, and these findings suggest that it may be possible simultaneously to target autoreactive or malignant cell survival(4). |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000402372800048 |
WOS关键词 | SPHINGOSINE-1-PHOSPHATE TRANSPORTER SPNS2 ; PROTEIN-COUPLED RECEPTOR ; LYMPHOCYTE EGRESS ; HOMEOSTASIS ; TRAFFICKING ; EXPRESSION ; APOPTOSIS ; THYMUS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/30447 |
专题 | 地球科学 |
作者单位 | 1.NYU, Sch Med, Skirball Inst Biomol Med, New York, NY 10016 USA; 2.Icahn Sch Med Mt Sinai, Dept Oncol Sci, New York, NY 10029 USA; 3.Weill Cornell Med Coll, Inst Computat Biomed, New York, NY 10021 USA; 4.Univ Oxford, Kennedy Inst Rheumatol, Roosevelt Dr, Oxford OX3 7FY, England; 5.Harvard Med Sch, Boston Childrens Hosp, Vasc Biol Program, Boston, MA 02115 USA |
推荐引用方式 GB/T 7714 | Mendoza, Alejandra,Fang, Victoria,Chen, Cynthia,et al. Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells[J]. NATURE,2017,546(7656):158-+. |
APA | Mendoza, Alejandra.,Fang, Victoria.,Chen, Cynthia.,Serasinghe, Madhavika.,Verma, Akanksha.,...&Schwab, Susan R..(2017).Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells.NATURE,546(7656),158-+. |
MLA | Mendoza, Alejandra,et al."Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells".NATURE 546.7656(2017):158-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论