Comment on “Ancient origins of allosteric activation in a Ser-Thr kinase”

GSTDTAP > 气候变化

DOI	10.1126/science.abc8301
	Comment on “Ancient origins of allosteric activation in a Ser-Thr kinase”
	Yeonwoo Park; Jaeda E. J. Patton; Georg K. A. Hochberg; Joseph W. Thornton
	2020-11-20
发表期刊	Science
出版年	2020
英文摘要	Hadzipasic et al . (Reports, 21 February 2020, p. 912) used ancestral sequence reconstruction to identify historical sequence substitutions that putatively caused Aurora kinases to evolve allosteric regulation. We show that their results arise from using an implausible phylogeny and sparse sequence sampling. Addressing either problem reverses their inferences: Allostery and the amino acids that confer it were not gained during the diversification of eukaryotes but were lost in a subgroup of Fungi.
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/304413
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Yeonwoo Park,Jaeda E. J. Patton,Georg K. A. Hochberg,等. Comment on “Ancient origins of allosteric activation in a Ser-Thr kinase”[J]. Science,2020.
APA	Yeonwoo Park,Jaeda E. J. Patton,Georg K. A. Hochberg,&Joseph W. Thornton.(2020).Comment on “Ancient origins of allosteric activation in a Ser-Thr kinase”.Science.
MLA	Yeonwoo Park,et al."Comment on “Ancient origins of allosteric activation in a Ser-Thr kinase”".Science (2020).