Tissue topography steers migrating <em>Drosophila</em> border cells

doi:10.1126/science.aaz4741

GSTDTAP > 气候变化

DOI	10.1126/science.aaz4741
	*Tissue topography steers migrating Drosophila* border cells**
	Wei Dai; Xiaoran Guo; Yuansheng Cao; James A. Mondo; Joseph P. Campanale; Brandon J. Montell; Haley Burrous; Sebastian Streichan; Nir Gov; Wouter-Jan Rappel; Denise J. Montell
	2020-11-20
发表期刊	Science
出版年	2020
英文摘要	For processes encompassing proper embryonic development, adult homeostasis, tumor cell dissemination, and immunity, certain cells must translocate from their site of origin. Migrating cells navigate physical features of their microenvironment; however, the in vivo importance of tissue topography for pathfinding is mostly unknown. Studying fruit flies, Dai et al. used border cells within the ovarian egg chamber to study path selection. Live imaging, genetics, mathematical modeling, and simulations showed that tissue microtopography provides an energetically favorable path of least resistance, whereas chemoattractants supply orthogonal guidance information and cell-cell adhesion contributes traction. The results provide insight into how cells integrate and prioritize topographical, adhesive, and chemoattractant cues to choose one path among many. Science , this issue p. [987][1] Moving cells can sense and respond to physical features of the microenvironment; however, in vivo, the significance of tissue topography is mostly unknown. Here, we used Drosophila border cells, an established model for in vivo cell migration, to study how chemical and physical information influences path selection. Although chemical cues were thought to be sufficient, live imaging, genetics, modeling, and simulations show that microtopography is also important. Chemoattractants promote predominantly posterior movement, whereas tissue architecture presents orthogonal information, a path of least resistance concentrated near the center of the egg chamber. E-cadherin supplies a permissive haptotactic cue. Our results provide insight into how cells integrate and prioritize topographical, adhesive, and chemoattractant cues to choose one path among many. [1]: /lookup/doi/10.1126/science.aaz4741
领域	气候变化 ; 资源环境
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/304409
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Wei Dai,Xiaoran Guo,Yuansheng Cao,et al. Tissue topography steers migrating Drosophila border cells[J]. Science,2020.
APA	Wei Dai.,Xiaoran Guo.,Yuansheng Cao.,James A. Mondo.,Joseph P. Campanale.,...&Denise J. Montell.(2020).Tissue topography steers migrating Drosophila border cells.Science.
MLA	Wei Dai,et al."Tissue topography steers migrating Drosophila border cells".Science (2020).