Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE

doi:10.1126/science.aba0864

GSTDTAP > 气候变化

DOI	10.1126/science.aba0864
	Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE
	Rasha Msallam; Jozef Balla; Abhay P. S. Rathore; Hassen Kared; Benoit Malleret; Wilfried A. A. Saron; Zhaoyuan Liu; Jing Wen Hang; Charles Antoine Dutertre; Anis Larbi; Jerry K. Y. Chan; Ashley L. St. John; Florent Ginhoux
	2020-11-20
发表期刊	Science
出版年	2020
英文摘要	Mast cells (MCs) are immune cells that participate in allergic reactions through their activation by immunoglobulin E (IgE) antibodies. MCs arise early during mammalian development, but it is unclear whether IgE-mediated activation occurs in fetal tissues and what the source of IgE stimulation is. Msallam et al. show that human and mouse fetal MCs can be sensitized by IgE of maternal origin, which crosses the placental barrier through the fetal neonatal Fc receptor (see the Perspective by Rothenberg). Prenatal maternal sensitization conferred transient allergen sensitivity after birth and resulted in the development of postnatal skin and airway inflammation in the offspring after their first exposure to allergen. Thus, both maternal IgE and fetal MCs may influence mother-to-child transmission of allergic disease during gestation. Science , this issue p. [941][1]; see also p. [907][2] Mast cells (MCs) are central effector cells in allergic reactions that are often mediated by immunoglobulin E (IgE). Allergies commonly start at an early age, and both MCs and IgE are detectable in fetuses. However, the origin of fetal IgE and whether fetal MCs can degranulate in response to IgE-dependent activation are presently unknown. Here, we show that human and mouse fetal MCs phenotypically mature through pregnancy and can be sensitized by maternal IgE. IgE crossed the placenta, dependent on the fetal neonatal Fc receptor (FcRN), and sensitized fetal MCs for allergen-specific degranulation. Both passive and active prenatal sensitization conferred allergen sensitivity, resulting in postnatal skin and airway inflammation after the first allergen encounter. We report a role for MCs within the developing fetus and demonstrate that fetal MCs may contribute to antigen-specific vertical transmission of allergic disease. [1]: /lookup/doi/10.1126/science.aba0864 [2]: /lookup/doi/10.1126/science.abe8283
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/304400
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Rasha Msallam,Jozef Balla,Abhay P. S. Rathore,et al. Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE[J]. Science,2020.
APA	Rasha Msallam.,Jozef Balla.,Abhay P. S. Rathore.,Hassen Kared.,Benoit Malleret.,...&Florent Ginhoux.(2020).Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE.Science.
MLA	Rasha Msallam,et al."Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE".Science (2020).