Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1073/pnas.2008925117 |
Modular genetic control of social status in a cichlid fish | |
Beau A. Alward; Vibhav A. Laud; Christopher J. Skalnik; Ryan A. York; Scott A. Juntti; Russell D. Fernald | |
2020-10-26 | |
发表期刊 | Proceedings of the National Academy of Sciences |
出版年 | 2020 |
英文摘要 | Social hierarchies are ubiquitous in social species and profoundly influence physiology and behavior. Androgens like testosterone have been strongly linked to social status, yet the molecular mechanisms regulating social status are not known. The African cichlid fish Astatotilapia burtoni is a powerful model species for elucidating the role of androgens in social status given their rich social hierarchy and genetic tractability. Dominant A. burtoni males possess large testes and bright coloration and perform aggressive and reproductive behaviors while nondominant males do not. Social status in A. burtoni is in flux, however, as males alter their status depending on the social environment. Due to a teleost-specific whole-genome duplication, A. burtoni possess two androgen receptor (AR) paralogs, ARα and ARβ, providing a unique opportunity to disentangle the role of gene duplication in the evolution of social systems. Here, we used CRISPR/Cas9 gene editing to generate AR mutant A. burtoni and performed a suite of experiments to interrogate the mechanistic basis of social dominance. We find that ARβ, but not ARα, is required for testes growth and bright coloration, while ARα, but not ARβ, is required for the performance of reproductive behavior and aggressive displays. Both receptors are required to reduce flees from females and either AR is sufficient for attacking males. Thus, social status in A. burtoni is inordinately dissociable and under the modular control of two AR paralogs. This type of nonredundancy may be important in facilitating social plasticity in A. burtoni and other species whose social status relies on social experience. |
领域 | 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/301958 |
专题 | 资源环境科学 |
推荐引用方式 GB/T 7714 | Beau A. Alward,Vibhav A. Laud,Christopher J. Skalnik,et al. Modular genetic control of social status in a cichlid fish[J]. Proceedings of the National Academy of Sciences,2020. |
APA | Beau A. Alward,Vibhav A. Laud,Christopher J. Skalnik,Ryan A. York,Scott A. Juntti,&Russell D. Fernald.(2020).Modular genetic control of social status in a cichlid fish.Proceedings of the National Academy of Sciences. |
MLA | Beau A. Alward,et al."Modular genetic control of social status in a cichlid fish".Proceedings of the National Academy of Sciences (2020). |
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