Comprehensive quantification of fuel use by the failing and nonfailing human heart

doi:10.1126/science.abc8861

GSTDTAP > 气候变化

DOI	10.1126/science.abc8861
	Comprehensive quantification of fuel use by the failing and nonfailing human heart
	Danielle Murashige; Cholsoon Jang; Michael Neinast; Jonathan J. Edwards; Alexis Cowan; Matthew C. Hyman; Joshua D. Rabinowitz; David S. Frankel; Zolt Arany
	2020-10-16
发表期刊	Science
出版年	2020
英文摘要	With heart failure a leading cause of death, a better understanding of metabolic function in the heart is a welcome advance. Murashige et al. measured more than 270 metabolites using liquid chromatography–mass spectrometry in human blood samples taken from an artery entering the heart and from a vein leaving it. Differences thus reflected the metabolic processes at work in the heart. Their results confirmed that hearts voraciously consume fatty acids. Hearts secreted, rather than consumed, amino acids, thus revealing active proteolysis. In patients with heart failure, ketone and lactate consumption increased, as did proteolysis. These findings could lead to strategies for fighting heart disease by altering metabolism. Science , this issue p. [364][1] The heart consumes circulating nutrients to fuel lifelong contraction, but a comprehensive mapping of human cardiac fuel use is lacking. We used metabolomics on blood from artery, coronary sinus, and femoral vein in 110 patients with or without heart failure to quantify the uptake and release of 277 metabolites, including all major nutrients, by the human heart and leg. The heart primarily consumed fatty acids and, unexpectedly, little glucose; secreted glutamine and other nitrogen-rich amino acids, indicating active protein breakdown, at a rate ~10 times that of the leg; and released intermediates of the tricarboxylic acid cycle, balancing anaplerosis from amino acid breakdown. Both heart and leg consumed ketones, glutamate, and acetate in direct proportionality to circulating levels, indicating that availability is a key driver for consumption of these substrates. The failing heart consumed more ketones and lactate and had higher rates of proteolysis. These data provide a comprehensive and quantitative picture of human cardiac fuel use. [1]: /lookup/doi/10.1126/science.abc8861
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/299350
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Danielle Murashige,Cholsoon Jang,Michael Neinast,et al. Comprehensive quantification of fuel use by the failing and nonfailing human heart[J]. Science,2020.
APA	Danielle Murashige.,Cholsoon Jang.,Michael Neinast.,Jonathan J. Edwards.,Alexis Cowan.,...&Zolt Arany.(2020).Comprehensive quantification of fuel use by the failing and nonfailing human heart.Science.
MLA	Danielle Murashige,et al."Comprehensive quantification of fuel use by the failing and nonfailing human heart".Science (2020).