An adhesion code ensures robust pattern formation during tissue morphogenesis

doi:10.1126/science.aba6637

GSTDTAP > 气候变化

DOI	10.1126/science.aba6637
	An adhesion code ensures robust pattern formation during tissue morphogenesis
	Tony Y.-C. Tsai; Mateusz Sikora; Peng Xia; Tugba Colak-Champollion; Holger Knaut; Carl-Philipp Heisenberg; Sean G. Megason
	2020-10-02
发表期刊	Science
出版年	2020
英文摘要	In embryo development, spatial patterns of distinct cell types arise reproducibly. In the zebrafish spinal cord, neural progenitors form stereotypic stripe patterns despite the noisy instructive signals and large-scale cellular rearrangement required during morphogenesis. Tsai et al. show that a cell type–specific adhesion code, regulated by a Shh morphogen gradient composed of three adhesion molecules, provides adhesion specificity for three neural progenitor types and mediates patterning robustness in the zebrafish spinal cord. Although insufficient on their own, the integration of the morphogen gradient and differential adhesion mechanisms enables robust pattern formation during tissue morphogenesis. Science , this issue p. [113][1] Animal development entails the organization of specific cell types in space and time, and spatial patterns must form in a robust manner. In the zebrafish spinal cord, neural progenitors form stereotypic patterns despite noisy morphogen signaling and large-scale cellular rearrangements during morphogenesis and growth. By directly measuring adhesion forces and preferences for three types of endogenous neural progenitors, we provide evidence for the differential adhesion model in which differences in intercellular adhesion mediate cell sorting. Cell type–specific combinatorial expression of different classes of cadherins (N-cadherin, cadherin 11, and protocadherin 19) results in homotypic preference ex vivo and patterning robustness in vivo. Furthermore, the differential adhesion code is regulated by the sonic hedgehog morphogen gradient. We propose that robust patterning during tissue morphogenesis results from interplay between adhesion-based self-organization and morphogen-directed patterning. [1]: /lookup/doi/10.1126/science.aba6637
领域	气候变化 ; 资源环境
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/298061
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Tony Y.-C. Tsai,Mateusz Sikora,Peng Xia,et al. An adhesion code ensures robust pattern formation during tissue morphogenesis[J]. Science,2020.
APA	Tony Y.-C. Tsai.,Mateusz Sikora.,Peng Xia.,Tugba Colak-Champollion.,Holger Knaut.,...&Sean G. Megason.(2020).An adhesion code ensures robust pattern formation during tissue morphogenesis.Science.
MLA	Tony Y.-C. Tsai,et al."An adhesion code ensures robust pattern formation during tissue morphogenesis".Science (2020).