Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through <i>in Vitro</i> Fertilization in Shanghai, China

doi:10.1289/EHP7076

GSTDTAP > 资源环境科学

DOI	10.1289/EHP7076
	*Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro* Fertilization in Shanghai, China**
	Peipei Hu; Angela Vinturache; Hong Li; Ying Tian; Lei Yuan; Chen Cai; Min Lu; Jiuru Zhao; Qianqian Zhang; Yu Gao; Zhiwei Liu; Guodong Ding
	2020-09-30
发表期刊	Environmental Health Perspectives
出版年	2020
英文摘要	Abstract Background: Animal studies suggest that pesticide exposure elicits endocrine changes, increases embryo implantation failure, and decreases litter size. However, only a few epidemiological studies have evaluated the effects of pesticides on the outcomes of in vitro fertilization (IVF) pregnancies. Objectives: This study examined the associations between preconception organophosphate pesticides (OP) exposure and pregnancy outcomes among women undergoing IVF in a Chinese population. Methods: This study included 522 women with infertility who underwent IVF. Women were recruited from a prospective study, the China National Birth Cohort (CNBC), from Shanghai, China, between July 2017 and December 2018. Demographic and clinical information were collected from medical records and through questionnaires. Preconception exposure to OP was assessed by measuring six nonspecific dialkylphosphate (DAP) metabolites [diethylthiophosphate (DETP), diethylphosphate (DEP), diethyldithiophosphate (DEDTP), dimethylthiophosphate (DMTP), dimethylphosphate (DMP), dimethyldithiophosphate (DMDTP)] in urine samples collected at recruitment. Generalized estimating equation (GEE) models were used to evaluate the associations between OP and pregnancy outcomes. Results: Compared with women in the lowest quartile ( $Uppercase q begin subscript 1 end subscript$ ) of individual DEP and $summation begin subscript 4 end subscript of dialkylphosphate$ (the sum of DMP, DMTP, DEP, and DETP), women in the highest quartile ( $Uppercase q begin subscript 4 end subscript$ ) had lower odds of successful implantation, clinical pregnancy, and live birth, and most of the negative trends were significant ( $lowercase italic p-trends less than 0.05$ ). There were no significant associations between urinary DAP concentrations and early IVF outcomes, including total and mature oocyte counts, best embryo quality, fertilization, $Uppercase e begin subscript 2 end subscript$ trigger levels, and endometrial wall thickness. Conclusion: Preconception OP exposure was inversely associated with successful implantation, clinical pregnancy, and live birth in women who underwent IVF. https://doi.org/10.1289/EHP7076
领域	资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/297767
专题	资源环境科学
推荐引用方式 GB/T 7714	Peipei Hu,Angela Vinturache,Hong Li,et al. Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China[J]. Environmental Health Perspectives,2020.
APA	Peipei Hu.,Angela Vinturache.,Hong Li.,Ying Tian.,Lei Yuan.,...&Guodong Ding.(2020).Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China.Environmental Health Perspectives.
MLA	Peipei Hu,et al."Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China".Environmental Health Perspectives (2020).