The immunogenetics of sexual parasitism

doi:10.1126/science.aaz9445

GSTDTAP > 气候变化

DOI	10.1126/science.aaz9445
	The immunogenetics of sexual parasitism
	Jeremy B. Swann; Stephen J. Holland; Malte Petersen; Theodore W. Pietsch; Thomas Boehm
	2020-09-25
发表期刊	Science
出版年	2020
英文摘要	The deep sea is a vast and generally empty environment. Finding a mate can thus be difficult. In response to this situation, one group of deep-sea denizens, the anglerfishes, have evolved a system in which males attach to females, in some cases permanently, through fusion of tissues and connection of circulatory systems. Such attachment greatly challenges the immune systems of the fish. Swann et al. found that these challenges have been met by the evolution of increasingly reduced immune responses among anglerfish species, including the loss of what have been considered essential vertebrate responses. These shifts suggest that vertebrate immune systems may be more flexible over evolutionary time than was previously thought. Science , this issue p. [1608][1] Sexual parasitism has evolved as a distinctive mode of reproduction among deep-sea anglerfishes. The permanent attachment of males to host females observed in these species represents a form of anatomical joining, which is otherwise unknown in nature. Pronounced modifications to immune facilities are associated with this reproductive trait. The genomes of species with temporarily attaching males lack functional aicda genes that underpin affinity maturation of antibodies. Permanent attachment is associated with additional alterations, culminating in the loss of functional rag genes in some species, abolishing somatic diversification of antigen receptor genes, the hallmark of canonical adaptive immunity. In anglerfishes, coevolution of innate and adaptive immunity has been disentangled, implying that an alternative form of immunity supported the emergence of this evolutionarily successful group of vertebrates. [1]: /lookup/doi/10.1126/science.aaz9445
领域	气候变化 ; 资源环境
URL	查看原文
引用统计	被引频次：35[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/296509
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Jeremy B. Swann,Stephen J. Holland,Malte Petersen,et al. The immunogenetics of sexual parasitism[J]. Science,2020.
APA	Jeremy B. Swann,Stephen J. Holland,Malte Petersen,Theodore W. Pietsch,&Thomas Boehm.(2020).The immunogenetics of sexual parasitism.Science.
MLA	Jeremy B. Swann,et al."The immunogenetics of sexual parasitism".Science (2020).