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How Plants Distinguish Beneficial from Harmful Microbes | |
admin | |
2020-08-07 | |
发布年 | 2020 |
语种 | 英语 |
国家 | 美国 |
领域 | 气候变化 |
正文(中文) | Legume plants fix atmospheric nitrogen with the help of symbiotic bacteria, called Rhizobia, which colonize their roots. Therefore, plants have to be able to precisely recognize their symbiont to avoid infection by pathogenic microbes. To this end, legumes use different LysM receptor proteins located on the outer cell surface of their roots. In the study published in Science, an international team of researchers led by Aarhus University show that pathogenic (chitin) or symbiotic signalling molecules (Nod factors) are recognized by small molecular motifs on the receptors that direct the signalling output towards either antimicrobial defence or symbiosis. All land plants have LysM receptors that ensure detection of various microbial signals, but how a plant decides to mount a symbiotic or an immune response towards an incoming microbe is unknown. "We started by asking a basic and, maybe at start, naïve question: Can we identify the important elements by using very similar receptors, but with opposing function as background for a systematic analysis?" says Zoltán Bozsoki. "The first crystal structure of a Nod factor receptor was a breakthrough. It gave us a better understanding of these receptors and guided our efforts to engineer them in plants." Kira Gysel adds. The study combines the structure-assisted dissection of defined regions in LysM receptors for biochemical experiments and in planta functional analysis. "To really understand these receptors, we needed to work closely together and combine structural biology and biochemistry with the systematic functional tests in plants," says Simon Boje Hansen. By using this approach, the researchers identified previously unknown motifs in the LysM1 domain of chitin and Nod factor receptors as determinants for immunity and symbiosis. "It turns out that there are only very few, but important, residues that separate an immune from a symbiotic receptor and we now identified these and demonstrate for the first time that it is possible to reprogram LysM receptors by changing these residues," says Kasper Røjkjær Andersen. The long-term goal is to transfer the unique nitrogen-fixing ability that legume plants have into cereal plants to limit the need for polluting commercial nitrogen fertilizers and to benefit and empower the poorest people on Earth. Simona Radutoiu concludes, "We now provide the conceptual understanding required for a stepwise and rational engineering of LysM receptors, which is an essential first step towards this ambitious goal."
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Story Source: Materials provided by Aarhus University. Original written by Lisbeth Heilesen. Note: Content may be edited for style and length. Journal Reference:
Cite This Page: Aarhus University. "How plants distinguish beneficial from harmful microbes." ScienceDaily. ScienceDaily, 7 August 2020.
Aarhus University. (2020, August 7). How plants distinguish beneficial from harmful microbes. ScienceDaily. Retrieved August 7, 2020 from www.sciencedaily.com/releases/2020/08/200807093758.htm
Aarhus University. "How plants distinguish beneficial from harmful microbes." ScienceDaily. www.sciencedaily.com/releases/2020/08/200807093758.htm (accessed August 7, 2020).
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正文(英文) | Legume plants fix atmospheric nitrogen with the help of symbiotic bacteria, called Rhizobia, which colonize their roots. Therefore, plants have to be able to precisely recognize their symbiont to avoid infection by pathogenic microbes. To this end, legumes use different LysM receptor proteins located on the outer cell surface of their roots. In the study published in Science, an international team of researchers led by Aarhus University show that pathogenic (chitin) or symbiotic signalling molecules (Nod factors) are recognized by small molecular motifs on the receptors that direct the signalling output towards either antimicrobial defence or symbiosis. All land plants have LysM receptors that ensure detection of various microbial signals, but how a plant decides to mount a symbiotic or an immune response towards an incoming microbe is unknown. "We started by asking a basic and, maybe at start, naïve question: Can we identify the important elements by using very similar receptors, but with opposing function as background for a systematic analysis?" says Zoltán Bozsoki. "The first crystal structure of a Nod factor receptor was a breakthrough. It gave us a better understanding of these receptors and guided our efforts to engineer them in plants." Kira Gysel adds. The study combines the structure-assisted dissection of defined regions in LysM receptors for biochemical experiments and in planta functional analysis. "To really understand these receptors, we needed to work closely together and combine structural biology and biochemistry with the systematic functional tests in plants," says Simon Boje Hansen. By using this approach, the researchers identified previously unknown motifs in the LysM1 domain of chitin and Nod factor receptors as determinants for immunity and symbiosis. "It turns out that there are only very few, but important, residues that separate an immune from a symbiotic receptor and we now identified these and demonstrate for the first time that it is possible to reprogram LysM receptors by changing these residues," says Kasper Røjkjær Andersen. The long-term goal is to transfer the unique nitrogen-fixing ability that legume plants have into cereal plants to limit the need for polluting commercial nitrogen fertilizers and to benefit and empower the poorest people on Earth. Simona Radutoiu concludes, "We now provide the conceptual understanding required for a stepwise and rational engineering of LysM receptors, which is an essential first step towards this ambitious goal."
make a difference: sponsored opportunity
Story Source: Materials provided by Aarhus University. Original written by Lisbeth Heilesen. Note: Content may be edited for style and length. Journal Reference:
Cite This Page: Aarhus University. "How plants distinguish beneficial from harmful microbes." ScienceDaily. ScienceDaily, 7 August 2020.
Aarhus University. (2020, August 7). How plants distinguish beneficial from harmful microbes. ScienceDaily. Retrieved August 7, 2020 from www.sciencedaily.com/releases/2020/08/200807093758.htm
Aarhus University. "How plants distinguish beneficial from harmful microbes." ScienceDaily. www.sciencedaily.com/releases/2020/08/200807093758.htm (accessed August 7, 2020).
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来源平台 | Science Daily |
文献类型 | 新闻 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/285753 |
专题 | 气候变化 |
推荐引用方式 GB/T 7714 | admin. How Plants Distinguish Beneficial from Harmful Microbes. 2020. |
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