Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition

doi:10.1126/science.aay9733

GSTDTAP > 气候变化

DOI	10.1126/science.aay9733
	Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition
	Jeff W. Chen; Tyler A. Rice; Jason M. Bannock; Agata A. Bielecka; Juliet D. Strauss; Jason R. Catanzaro; Haowei Wang; Laurence C. Menard; Jennifer H. Anolik; Noah W. Palm; Eric Meffre
	2020-07-17
发表期刊	Science
出版年	2020
英文摘要	Extensive immunoglobulin gene rearrangements allow humans to recognize a diversity of potential pathogens. This antibody repertoire is more restricted during early life to prevent the generation of autoreactive B cells, though tolerance does not appear to be complete. Chen et al. examined the reactivities of antibodies cloned from individual human fetal B cells residing in the liver, bone marrow, and spleen. They observed the accumulation of autoreactive and polyreactive B cells, which were frequently cross-reactive to commensals in the absence of any somatic hypermutation. The generation of these reactive B cells before they are ever exposed to microbes may promote later beneficial commensal- host interactions and/or augmented host defense during the first weeks of life. Science this issue p. [320][1] Restricted V(D)J recombination during fetal development was postulated to limit antibody repertoire breadth and prevent autoimmunity. However, newborn serum contains abundant autoantibodies, suggesting that B cell tolerance during gestation is not yet fully established. To investigate this apparent paradox, we evaluated the reactivities of more than 450 antibodies cloned from single B cells from human fetal liver, bone marrow, and spleen. We found that incomplete B cell tolerance in early human fetal life favored the accumulation of polyreactive B cells that bound both apoptotic cells and commensal bacteria from healthy adults. Thus, the restricted fetal preimmune repertoire contains potentially beneficial self-reactive innate-like B cell specificities that may facilitate the removal of apoptotic cells during development and shape gut microbiota assembly after birth. [1]: /lookup/doi/10.1126/science.aay9733
领域	气候变化 ; 资源环境
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/284354
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Jeff W. Chen,Tyler A. Rice,Jason M. Bannock,et al. Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition[J]. Science,2020.
APA	Jeff W. Chen.,Tyler A. Rice.,Jason M. Bannock.,Agata A. Bielecka.,Juliet D. Strauss.,...&Eric Meffre.(2020).Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition.Science.
MLA	Jeff W. Chen,et al."Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition".Science (2020).