A brainwide atlas of synapses across the mouse life span

doi:10.1126/science.aba3163

GSTDTAP > 气候变化

DOI	10.1126/science.aba3163
	A brainwide atlas of synapses across the mouse life span
	Mélissa Cizeron; Zhen Qiu; Babis Koniaris; Ragini Gokhale; Noboru H. Komiyama; Erik Fransén; Seth G. N. Grant
	2020-07-17
发表期刊	Science
出版年	2020
英文摘要	Excitatory synapses connect neurons in the brain to build the circuits that enable behavior. Cizeron et al. surveyed synapses in the mouse brain from birth to old age and present the data as a community resource, the Mouse Lifespan Synaptome Atlas (see the Perspective by Micheva et al. ). Molecular and morphological features defined 37 subtypes of synapses. Although synapse density generally increased in early development and declined in old age, the details differed in different brain areas. Science this issue p. [270][1]; see also p. [253][2] Synapses connect neurons together to form the circuits of the brain, and their molecular composition controls innate and learned behavior. We analyzed the molecular and morphological diversity of 5 billion excitatory synapses at single-synapse resolution across the mouse brain from birth to old age. A continuum of changes alters synapse composition in all brain regions across the life span. Expansion in synapse diversity produces differentiation of brain regions until early adulthood, and compositional changes cause dedifferentiation in old age. The spatiotemporal synaptome architecture of the brain potentially accounts for life-span transitions in intellectual ability, memory, and susceptibility to behavioral disorders. [1]: /lookup/doi/10.1126/science.aba3163 [2]: /lookup/doi/10.1126/science.abc9555
领域	气候变化 ; 资源环境
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文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/284343
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Mélissa Cizeron,Zhen Qiu,Babis Koniaris,et al. A brainwide atlas of synapses across the mouse life span[J]. Science,2020.
APA	Mélissa Cizeron.,Zhen Qiu.,Babis Koniaris.,Ragini Gokhale.,Noboru H. Komiyama.,...&Seth G. N. Grant.(2020).A brainwide atlas of synapses across the mouse life span.Science.
MLA	Mélissa Cizeron,et al."A brainwide atlas of synapses across the mouse life span".Science (2020).