Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain

doi:10.1126/science.aaw2622

GSTDTAP > 气候变化

DOI	10.1126/science.aaw2622
	Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain
	Alana M. Horowitz; Xuelai Fan; Gregor Bieri; Lucas K. Smith; Cesar I. Sanchez-Diaz; Adam B. Schroer; Geraldine Gontier; Kaitlin B. Casaletto; Joel H. Kramer; Katherine E. Williams; Saul A. Villeda
	2020-07-10
发表期刊	Science
出版年	2020
英文摘要	Exercise has a broad range of beneficial healthful effects. Horowitz et al. tested whether the beneficial effects of exercise on neurogenesis in the brain and improved cognition in aged mice could be transferred in plasma (blood without its cellular components) from one mouse to another (see the Perspective by Ansere and Freeman). Indeed, aged mice that received plasma from young or old mice that had exercised showed beneficial effects in their brains without hitting the treadmill. The authors identified glycosylphosphatidylinositol-specific phospholipase D1 as a factor in plasma that might, in part, mediate this favorable effect. Science , this issue p. [167][1]; see also p. [144][2] Reversing brain aging may be possible through systemic interventions such as exercise. We found that administration of circulating blood factors in plasma from exercised aged mice transferred the effects of exercise on adult neurogenesis and cognition to sedentary aged mice. Plasma concentrations of glycosylphosphatidylinositol (GPI)–specific phospholipase D1 (Gpld1), a GPI-degrading enzyme derived from liver, were found to increase after exercise and to correlate with improved cognitive function in aged mice, and concentrations of Gpld1 in blood were increased in active, healthy elderly humans. Increasing systemic concentrations of Gpld1 in aged mice ameliorated age-related regenerative and cognitive impairments by altering signaling cascades downstream of GPI-anchored substrate cleavage. We thus identify a liver-to-brain axis by which blood factors can transfer the benefits of exercise in old age. [1]: /lookup/doi/10.1126/science.aaw2622 [2]: /lookup/doi/10.1126/science.abc8830
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/283397
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Alana M. Horowitz,Xuelai Fan,Gregor Bieri,et al. Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain[J]. Science,2020.
APA	Alana M. Horowitz.,Xuelai Fan.,Gregor Bieri.,Lucas K. Smith.,Cesar I. Sanchez-Diaz.,...&Saul A. Villeda.(2020).Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain.Science.
MLA	Alana M. Horowitz,et al."Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain".Science (2020).