Number of HIV-1 founder variants is determined by the recency of the source partner infection

doi:10.1126/science.aba5443

GSTDTAP > 气候变化

DOI	10.1126/science.aba5443
	Number of HIV-1 founder variants is determined by the recency of the source partner infection
	Ch. Julián Villabona-Arenas; Matthew Hall; Katrina A. Lythgoe; Stephen G. Gaffney; Roland R. Regoes; Stéphane Hué; Katherine E. Atkins
	2020-07-03
发表期刊	Science
出版年	2020
英文摘要	HIV-1 has a multitude of strain variants, but sexual transmission of HIV-1 is assumed to result from productive infection by only one virus particle. Knowing the genetics of the virus strains that are transmitted could be crucial for developing successful vaccine strategies. Using epidemiological and genetic data from 112 pairs of sexual partners, Villabona-Arenas et al. found that individuals with acute infections are more likely to transmit multiple founder virus strains. In a phylodynamic approach that integrated phylogenetic analysis of sequence data with simulation of a transmission chain, the authors showed that multiple variant transmission is doubled during the first 3 months of infection irrespective of whether transmission was heterosexual or by men who have sex with men. Science , this issue p. [103][1] During sexual transmission, the high genetic diversity of HIV-1 within an individual is frequently reduced to one founder variant that initiates infection. Understanding the drivers of this bottleneck is crucial to developing effective infection control strategies. Little is known about the importance of the source partner during this bottleneck. To test the hypothesis that the source partner affects the number of HIV founder variants, we developed a phylodynamic model calibrated using genetic and epidemiological data on all existing transmission pairs for whom the direction of transmission and the infection stage of the source partner are known. Our results suggest that acquiring infection from someone in the acute (early) stage of infection increases the risk of multiple–founder variant transmission compared with acquiring infection from someone in the chronic (later) stage of infection. This study provides the first direct test of source partner characteristics to explain the low frequency of multiple–founder strain infections. [1]: /lookup/doi/10.1126/science.aba5443
领域	气候变化 ; 资源环境
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/281896
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Ch. Julián Villabona-Arenas,Matthew Hall,Katrina A. Lythgoe,et al. Number of HIV-1 founder variants is determined by the recency of the source partner infection[J]. Science,2020.
APA	Ch. Julián Villabona-Arenas.,Matthew Hall.,Katrina A. Lythgoe.,Stephen G. Gaffney.,Roland R. Regoes.,...&Katherine E. Atkins.(2020).Number of HIV-1 founder variants is determined by the recency of the source partner infection.Science.
MLA	Ch. Julián Villabona-Arenas,et al."Number of HIV-1 founder variants is determined by the recency of the source partner infection".Science (2020).