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DOI | 10.1038/s41586-019-1922-8 |
B cells and tertiary lymphoid structures promote immunotherapy response | |
Zhang, Liangsheng1,2; Chen, Fei1,2,3; Zhang, Xingtan1,2; Li, Zhen4,5; Zhao, Yiyong6; Lohaus, Rolf4,5; Chang, Xiaojun1,2,8; Dong, Wei1,2; Ho, Simon Y. W.9; Liu, Xing1,2; Song, Aixia1,2; Chen, Junhao10; Guo, Wenlei10; Wang, Zhengjia10; Zhuang, Yingyu1,2; Wang, Haifeng1,2; Chen, Xuequn1,2; Hu, Juan1,2; Liu, Yanhui1,2; Qin, Yuan1,2; Wang, Kai; Dong, Shanshan8; Liu, Yang8,11; Zhang, Shouzhou8; Yu, Xianxian12; Wu, Qian13; Wang, Liangsheng13,14; Yan, Xueqing14,15; Jiao, Yuannian14,15; Kong, Hongzhi14,15; Zhou, Xiaofan16; Yu, Cuiwei17; Chen, Yuchu17; Li, Fan18; Wang, Jihua18; Chen, Wei19; Chen, Xinlu20; Jia, Qidong21; Zhang, Chi20; Jiang, Yifan; Zhang, Wanbo3; Liu, Guanhua22; Fu, Jianyu22; Chen, Feng3,21; Ma, Hong7; Van de Peer, Yves4,5,23; Tang, Haibao1,2,3,5 | |
2020-01-02 | |
发表期刊 | NATURE |
ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2020 |
卷号 | 577期号:7791页码:549-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Netherlands; France |
英文关键词 | Multiomic profiling of several cohorts of patients treated with immune checkpoint blockade highlights the presence and potential role of B cells and tertiary lymphoid structures in promoting therapy response. Treatment with immune checkpoint blockade (ICB) has revolutionized cancer therapy. Until now, predictive biomarkers(1-10) and strategies to augment clinical response have largely focused on the T cell compartment. However, other immune subsets may also contribute to anti-tumour immunity(11-15), although these have been less well-studied in ICB treatment(16). A previously conducted neoadjuvant ICB trial in patients with melanoma showed via targeted expression profiling(17) that B cell signatures were enriched in the tumours of patients who respond to treatment versus non-responding patients. To build on this, here we performed bulk RNA sequencing and found that B cell markers were the most differentially expressed genes in the tumours of responders versus non-responders. Our findings were corroborated using a computational method (MCP-counter(18)) to estimate the immune and stromal composition in this and two other ICB-treated cohorts (patients with melanoma and renal cell carcinoma). Histological evaluation highlighted the localization of B cells within tertiary lymphoid structures. We assessed the potential functional contributions of B cells via bulk and single-cell RNA sequencing, which demonstrate clonal expansion and unique functional states of B cells in responders. Mass cytometry showed that switched memory B cells were enriched in the tumours of responders. Together, these data provide insights into the potential role of B cells and tertiary lymphoid structures in the response to ICB treatment, with implications for the development of biomarkers and therapeutic targets. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000508287700003 |
WOS关键词 | IMMUNE CONTEXTURE ; DENDRITIC CELLS ; MELANOMA ; CANCER ; LYMPHOCYTES ; BIOMARKERS ; CYTOSCAPE ; DENSITY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/281421 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Fujian Agr & Forestry Univ, Fujian Prov Key Lab Haixia Appl Plant Syst Biol, Minist Educ Genet Breeding & Multiple Utilizat Ct, Key Lab Natl Forestry,Key Lab, Fuzhou, Fujian, Peoples R China; 2.Fujian Agr & Forestry Univ, Grassland Adm Orchid Conservat & Utilizat, Fuzhou, Fujian, Peoples R China; 3.Nanjing Agr Univ, Coll Hort, Nanjing, Jiangsu, Peoples R China; 4.Univ Ghent, Dept Plant Biotechnol & Bioinformat, Ghent, Belgium; 5.VIB Ctr Plant Syst Biol, Ghent, Belgium; 6.Fudan Univ, Sch Life Sci, Key Lab Biodivers Sci & Ecol Engn, State Key Lab Genet Engn,Minist Educ, Shanghai, Peoples R China; 7.Penn State Univ, Huck Inst Life Sci, Dept Biol, University Pk, PA 16802 USA; 8.Shenzhen & Chinese Acad Sci, Fairy Lake Bot Garden, Shenzhen, Guangdong, Peoples R China; 9.Univ Sydney, Sch Life & Environm Sci, Sydney, NSW, Australia; 10.Zhejiang A&F Univ, Sch Forestry & Biotechnol, State Key Lab Subtrop Silviculture, Hangzhou, Zhejiang, Peoples R China; 11.BGI Shenzhen, Shenzhen, Guangdong, Peoples R China; 12.Xuchang Univ, Sch Urban Rural Planning & Landscape Architecture, Xuchang, Peoples R China; 13.Chinese Acad Sci, Inst Bot, Beijing Bot Garden, Key Lab Plant Resources, Beijing, Peoples R China; 14.Univ Chinese Acad Sci, Beijing, Peoples R China; 15.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing, Peoples R China; 16.South China Agr Univ, Integrat Microbiol Res Ctr, Guangdong Prov Key Lab Microbial Signals & Dis, Guangzhou, Guangdong, Peoples R China; 17.Zhejiang Humanities Landscape Co Ltd, Hangzhou Tianjing Aquat Bot Garden, Hangzhou, Zhejiang, Peoples R China; 18.Yunnan Acad Agr Sci, Floriculture Res Inst, Key Lab Flower Breeding Yunnan Prov, Natl Engn Res Ctr Ornamental Hort, Kunming, Yunnan, Peoples R China; 19.Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu, Sichuan, Peoples R China; 20.Univ Tennessee, Dept Plant Sci, Knoxville, TN USA; 21.Univ Tennessee, Grad Sch Genome Sci & Technol, Knoxville, TN USA; 22.Chinese Acad Agr Sci, Tea Res Inst, Minist Agr & Rural Affairs, Key Lab Tea Qual & Safety Control, Hangzhou, Zhejiang, Peoples R China; 23.Univ Pretoria, Ctr Microbial Ecol & Genom, Dept Biochem Genet & Microbiol, Pretoria, South Africa |
推荐引用方式 GB/T 7714 | Zhang, Liangsheng,Chen, Fei,Zhang, Xingtan,et al. B cells and tertiary lymphoid structures promote immunotherapy response[J]. NATURE,2020,577(7791):549-+. |
APA | Zhang, Liangsheng.,Chen, Fei.,Zhang, Xingtan.,Li, Zhen.,Zhao, Yiyong.,...&Tang, Haibao.(2020).B cells and tertiary lymphoid structures promote immunotherapy response.NATURE,577(7791),549-+. |
MLA | Zhang, Liangsheng,et al."B cells and tertiary lymphoid structures promote immunotherapy response".NATURE 577.7791(2020):549-+. |
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