DOI | 10.1038/s41586-020-2015-4
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| ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity |
| Papai, Gabor1,2,3,4; Frechard, Alexandre1,2,3,4; Kolesnikova, Olga1,2,3,4; Crucifix, Corinne1,2,3,4; Schultz, Patrick1,2,3,4; Ben-Shem, Adam1,2,3,4
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| 2020-01-30
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发表期刊 | NATURE
![](/C666/image/waiting.gif) |
ISSN | 0028-0836
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EISSN | 1476-4687
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出版年 | 2020
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文章类型 | Article;Early Access
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语种 | 英语
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国家 | USA |
英文关键词 | Tumour-infiltrating group 2 innate lymphoid cells prime CD8(+) T cells and amplify the anti-tumour effects of PD-1 blockade in pancreatic ductal adenocarcinoma.
Group 2 innate lymphoid cells (ILC2s) regulate inflammation and immunity in mammalian tissues(1,2). Although ILC2s are found in cancers of these tissues(3), their roles in cancer immunity and immunotherapy are unclear. Here we show that ILC2s infiltrate pancreatic ductal adenocarcinomas (PDACs) to activate tissue-specific tumour immunity. Interleukin-33 (IL33) activates tumour ILC2s (TILC2s) and CD8(+) T cells in orthotopic pancreatic tumours but not heterotopic skin tumours in mice to restrict pancreas-specific tumour growth. Resting and activated TILC2s express the inhibitory checkpoint receptor PD-1. Antibody-mediated PD-1 blockade relieves ILC2 cell-intrinsic PD-1 inhibition to expand TILC2s, augment anti-tumour immunity, and enhance tumour control, identifying activated TILC2s as targets of anti-PD-1 immunotherapy. Finally, both PD-1(+) TILC2s and PD-1(+) T cells are present in most human PDACs. Our results identify ILC2s as anti-cancer immune cells for PDAC immunotherapy. More broadly, ILC2s emerge as tissue-specific enhancers of cancer immunity that amplify the efficacy of anti-PD-1 immunotherapy. As ILC2s and T cells co-exist in human cancers and share stimulatory and inhibitory pathways, immunotherapeutic strategies to collectively target anti-cancer ILC2s and T cells may be broadly applicable.
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领域 | 地球科学
; 气候变化
; 资源环境
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收录类别 | SCI-E
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WOS记录号 | WOS:000518176200002
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WOS关键词 | INNATE LYMPHOID-CELLS
; PROMOTES
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WOS类目 | Multidisciplinary Sciences
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WOS研究方向 | Science & Technology - Other Topics
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引用统计 |
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文献类型 | 期刊论文
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条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/281416
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专题 | 地球科学 资源环境科学 气候变化
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作者单位 | 1.Inst Genet & Biol Mol & Cellulaire, Integrated Struct Biol Dept, Equipe Labellisee Ligue Canc, Illkirch Graffenstaden, France; 2.CNRS, UMR7104, Illkirch Graffenstaden, France; 3.INSERM, U1258, Illkirch Graffenstaden, France; 4.Univ Strasbourg, Illkirch Graffenstaden, France
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推荐引用方式 GB/T 7714 |
Papai, Gabor,Frechard, Alexandre,Kolesnikova, Olga,et al. ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity[J].
NATURE,2020.
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APA |
Papai, Gabor,Frechard, Alexandre,Kolesnikova, Olga,Crucifix, Corinne,Schultz, Patrick,&Ben-Shem, Adam.(2020).ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity.NATURE.
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MLA |
Papai, Gabor,et al."ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity".NATURE (2020).
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