Giant virus diversity and host interactions through global metagenomics

doi:10.1038/s41586-020-1957-x

GSTDTAP > 地球科学

DOI	10.1038/s41586-020-1957-x
	Giant virus diversity and host interactions through global metagenomics
	Su, Jie 1; Morgani, Sophie M.2,3; David, Charles J.1,6; Wang, Qiong 1,7; Er, Ekrem Emrah 1; Huang, Yun-Han 1,4; Basnet, Harihar 1; Zou, Yilong 1,4,8; Shu, Weiping 1; Soni, Rajesh K.5; Hendrickson, Ronald C.5; Hadjantonakis, Anna-Katerina 2; Massague, Joan 1
	2020-01-08
发表期刊	NATURE
ISSN	0028-0836
EISSN	1476-4687
出版年	2020
页码	1-+
文章类型	Article;Early Access
语种	英语
国家	USA; Canada
英文关键词	Analysis of metagenomics data revealed that large and giant viruses are globally widely distributed and are associated with most major eukaryotic lineages. Our current knowledge about nucleocytoplasmic large DNA viruses (NCLDVs) is largely derived from viral isolates that are co-cultivated with protists and algae. Here we reconstructed 2,074 NCLDV genomes from sampling sites across the globe by building on the rapidly increasing amount of publicly available metagenome data. This led to an 11-fold increase in phylogenetic diversity and a parallel 10-fold expansion in functional diversity. Analysis of 58,023 major capsid proteins from large and giant viruses using metagenomic data revealed the global distribution patterns and cosmopolitan nature of these viruses. The discovered viral genomes encoded a wide range of proteins with putative roles in photosynthesis and diverse substrate transport processes, indicating that host reprogramming is probably a common strategy in the NCLDVs. Furthermore, inferences of horizontal gene transfer connected viral lineages to diverse eukaryotic hosts. We anticipate that the global diversity of NCLDVs that we describe here will establish giant viruses-which are associated with most major eukaryotic lineages-as important players in ecosystems across Earth' s biomes.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000513111000001
WOS关键词	DNA VIRUSES ; PROTEIN ; GENOME ; RHODOPSINS ; ALIGNMENT ; MIMIVIRIDAE ; ANNOTATION ; EVOLUTION ; FAMILIES ; BACTERIA
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/281355
专题	地球科学资源环境科学气候变化
作者单位	1.Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Canc Biol & Genet Program, 1275 York Ave, New York, NY 10021 USA; 2.Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Dev Biol Program, 1275 York Ave, New York, NY 10021 USA; 3.Univ Cambridge, Ctr Stem Cell Res, Wellcome Trust Med Res Council, Cambridge, England; 4.Mem Sloan Kettering Canc Ctr, Gerstner Sloan Kettering Grad Sch Biomed Sci, 1275 York Ave, New York, NY 10021 USA; 5.Mem Sloan Kettering Canc Ctr, Microchem & Prote, 1275 York Ave, New York, NY 10021 USA; 6.Tsinghua Univ, Dept Basic Sci, Sch Med, Beijing, Peoples R China; 7.Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Reprod Med, Dept Histoembryol Genet & Dev Biol, Shanghai, Peoples R China; 8.Broad Inst, Chem Biol & Therapeut Sci Program, Cambridge, MA USA
推荐引用方式 GB/T 7714	Su, Jie,Morgani, Sophie M.,David, Charles J.,et al. Giant virus diversity and host interactions through global metagenomics[J]. NATURE,2020:1-+.
APA	Su, Jie.,Morgani, Sophie M..,David, Charles J..,Wang, Qiong.,Er, Ekrem Emrah.,...&Massague, Joan.(2020).Giant virus diversity and host interactions through global metagenomics.NATURE,1-+.
MLA	Su, Jie,et al."Giant virus diversity and host interactions through global metagenomics".NATURE (2020):1-+.