Structural basis of receptor recognition by SARS-CoV-2

doi:10.1038/s41586-020-2179-y

GSTDTAP > 地球科学

DOI	10.1038/s41586-020-2179-y
	Structural basis of receptor recognition by SARS-CoV-2
	Ehrenreich, David 1; 39;Odorico, Valentina 2
	2020-03-18
发表期刊	NATURE
ISSN	0028-0836
EISSN	1476-4687
出版年	2020
卷号	581 期号:7807 页码:221-+
文章类型	Article
语种	英语
国家	USA
英文关键词	A novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) recently emerged and is rapidly spreading in humans, causing COVID-19(1,2). A key to tackling this pandemic is to understand the receptor recognition mechanism of the virus, which regulates its infectivity, pathogenesis and host range. SARS-CoV-2 and SARS-CoV recognize the same receptor-angiotensin-converting enzyme 2 (ACE2)-in humans(3,4). Here we determined the crystal structure of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 (engineered to facilitate crystallization) in complex with ACE2. In comparison with the SARS-CoV RBD, an ACE2-binding ridge in SARS-CoV-2 RBD has a more compact conformation moreover, several residue changes in the SARS-CoV-2 RBD stabilize two virus-binding hotspots at the RBD-ACE2 interface. These structural features of SARS-CoV-2 RBD increase its ACE2-binding affinity. Additionally, we show that RaTG13, a bat coronavirus that is closely related to SARS-CoV-2, also uses human ACE2 as its receptor. The differences among SARS-CoV-2, SARS-CoV and RaTG13 in ACE2 recognition shed light on the potential animal-to-human transmission of SARS-CoV-2. This study provides guidance for intervention strategies that target receptor recognition by SARS-CoV-2.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000532836000034
WOS关键词	ACUTE RESPIRATORY SYNDROME ; SARS-CORONAVIRUS ; SPIKE PROTEIN ; ADAPTATION ; TARGET ; COV
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/281353
专题	地球科学资源环境科学气候变化
作者单位	1.Univ Geneva, Observ Astron, Versoix, Switzerland; 2.CSIC, INTA, Ctr Astrobiol, Torrejon De Ardoz, Spain; 3.INAF Osservatorio Astron Trieste, Trieste, Italy; 4.Inst Astrofis Canarias, Tenerife, Spain; 5.Univ Porto, CAUP, Inst Astrofis & Ciencias Espaco, Porto, Portugal; 6.Univ Porto, Fac Ciencias, Dept Fis & Astron, Porto, Portugal; 7.INAF Osservatorio Astron Brera, Merate, Italy; 8.Univ Lisbon, Inst Astrofis & Ciencias Espaco, Lisbon, Portugal; 9.Univ Lisbon, Dept Fis, Fac Ciencias, Lisbon, Portugal; 10.Univ Bern, Phys Inst, Bern, Switzerland; 11.Univ Bern, Ctr Space & Habitabil, Bern, Switzerland; 12.European Southern Observ, Garching, Germany; 13.Scuola Normale Super Pisa, Pisa, Italy; 14.European Southern Observ, Santiago, Chile; 15.Austrian Acad Sci, Space Res Inst, Graz, Austria; 16.Univ Porto, Ctr Astrofis, Porto, Portugal; 17.INAF Osservatorio Astron Palermo, Palermo, Italy; 18.Inst Fundamental Phys Universe, Miramare, Italy; 19.Fdn Galileo Galilei, INAF, Brena Baja, Spain; 20.INAF Osservatorio Astrofis Torino, Pino Torinese, Italy
推荐引用方式 GB/T 7714	Ehrenreich, David,39;Odorico, Valentina. Structural basis of receptor recognition by SARS-CoV-2[J]. NATURE,2020,581(7807):221-+.
APA	Ehrenreich, David,&39;Odorico, Valentina.(2020).Structural basis of receptor recognition by SARS-CoV-2.NATURE,581(7807),221-+.
MLA	Ehrenreich, David,et al."Structural basis of receptor recognition by SARS-CoV-2".NATURE 581.7807(2020):221-+.