DOI | 10.1038/s41586-020-2159-2
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| A satellite repeat-derived piRNA controls embryonic development of Aedes |
| Wagner, Felix R.1; Dienemann, Christian1; Wang, Haibo1; Stuetzer, Alexandra2; Tegunov, Dimitry1; Urlaub, Henning2,3; Cramer, Patrick1
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| 2020-03-01
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发表期刊 | NATURE
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ISSN | 0028-0836
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EISSN | 1476-4687
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出版年 | 2020
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卷号 | 580期号:7802页码:274-+ |
文章类型 | Article
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语种 | 英语
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国家 | Netherlands; France; USA |
英文关键词 | Tandem repeat elements such as the diverse class of satellite repeats occupy large parts of eukaryotic chromosomes, mostly at centromeric, pericentromeric, telomeric and subtelomeric regions(1). However, some elements are located in euchromatic regions throughout the genome and have been hypothesized to regulate gene expression in cis by modulating local chromatin structure, or in trans via transcripts derived from the repeats(2-4). Here we show that a satellite repeat in the mosquito Aedes aegypti promotes sequence-specific gene silencing via the expression of two PIWI-interacting RNAs (piRNAs). Whereas satellite repeats and piRNA sequences generally evolve extremely quickly(5-7), this locus was conserved for approximately 200 million years, suggesting that it has a central function in mosquito biology. piRNA production commenced shortly after egg laying, and inactivation of the more abundant piRNA resulted in failure to degrade maternally deposited transcripts in the zygote and developmental arrest. Our results reveal a mechanism by which satellite repeats regulate global gene expression in trans via piRNA-mediated gene silencing that is essential for embryonic development.
A conserved satellite repeat in the mosquito Aedes aegypti encodes PIWI-interacting RNAs that promote sequence-specific gene silencing in trans and have an essential role in embryonic development.
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领域 | 地球科学
; 气候变化
; 资源环境
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收录类别 | SCI-E
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WOS记录号 | WOS:000522805400004
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WOS关键词 | SINDBIS VIRUS
; MOSQUITO
; REVEALS
; POLY(A)
; DECAY
; TRANSCRIPTS
; EXPRESSION
; ARBOVIRUS
; AEGYPTI
; PCR
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WOS类目 | Multidisciplinary Sciences
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WOS研究方向 | Science & Technology - Other Topics
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引用统计 |
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文献类型 | 期刊论文
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条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/281267
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专题 | 地球科学 资源环境科学 气候变化
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作者单位 | 1.Max Planck Inst BioPhys Chem, Dept Mol Biol, Gottingen, Germany; 2.Max Planck Inst Biophys Chem, Bioanalyt Mass Spectrometry, Gottingen, Germany; 3.Univ Med Ctr Gottingen, Inst Clin Chem, Bioanalyt Grp, Gottingen, Germany
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推荐引用方式 GB/T 7714 |
Wagner, Felix R.,Dienemann, Christian,Wang, Haibo,et al. A satellite repeat-derived piRNA controls embryonic development of Aedes[J].
NATURE,2020,580(7802):274-+.
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APA |
Wagner, Felix R..,Dienemann, Christian.,Wang, Haibo.,Stuetzer, Alexandra.,Tegunov, Dimitry.,...&Cramer, Patrick.(2020).A satellite repeat-derived piRNA controls embryonic development of Aedes.NATURE,580(7802),274-+.
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MLA |
Wagner, Felix R.,et al."A satellite repeat-derived piRNA controls embryonic development of Aedes".NATURE 580.7802(2020):274-+.
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