Injured adult neurons regress to an embryonic transcriptional growth state

doi:10.1038/s41586-020-2200-5

GSTDTAP > 地球科学

DOI	10.1038/s41586-020-2200-5
	Injured adult neurons regress to an embryonic transcriptional growth state
	Wang, Ruicong 1,2; Li, Hongda 1,2; Wu, Jianfeng 1,2; Cai, Zhi-Yu 1,2; Li, Baizhou 3; Ni, Hengxiao 1,2; Qiu, Xingfeng 4; Chen, Hui 5; Liu, Wei 1,2; Yang, Zhang-Hua 1,2; Liu, Min 1,2; Hu, Jin 1,2; Liang, Yaoji 1; Lan, Ping 6; Han, Jiahuai 1,2; Mo, Wei 1,2
	2020-04-16
发表期刊	NATURE
ISSN	0028-0836
EISSN	1476-4687
出版年	2020
卷号	581 期号:7806 页码:77-+
文章类型	Article
语种	英语
国家	USA
英文关键词	Grafts of spinal-cord-derived neural progenitor cells (NPCs) enable the robust regeneration of corticospinal axons and restore forelimb function after spinal cord injury(1) however, the molecular mechanisms that underlie this regeneration are unknown. Here we perform translational profiling specifically of corticospinal tract (CST) motor neurons in mice, to identify their ' regenerative transcriptome' after spinal cord injury and NPC grafting. Notably, both injury alone and injury combined with NPC grafts elicit virtually identical early transcriptomic responses in host CST neurons. However, in mice with injury alone this regenerative transcriptome is downregulated after two weeks, whereas in NPC-grafted mice this transcriptome is sustained. The regenerative transcriptome represents a reversion to an embryonic transcriptional state of the CST neuron. The huntingtin gene (Htt) is a central hub in the regeneration transcriptome deletion of Htt significantly attenuates regeneration, which shows that Htt has a key role in neural plasticity after injury. In mouse models of central nervous system injury, Htt is shown to be a key component of the regulatory program associated with reversion of the neuronal transcriptome to a less-mature state.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000530868200012
WOS关键词	TRANSLATIONAL PROFILING APPROACH ; HUNTINGTONS-DISEASE ; AXON REGENERATION ; FUNCTIONAL RECOVERY ; CNS ; CONNECTIVITY ; INACTIVATION ; EXPRESSION ; SYNAPSE ; ABILITY
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/281232
专题	地球科学资源环境科学气候变化
作者单位	1.Xiamen Univ, Sch Life Sci, Innovat Ctr Cell Signaling Network, State Key Lab Cellular Stress Biol, Xiamen, Peoples R China; 2.Xiamen Univ, Sch Med, Xiangan Hosp, Canc Res Ctr, Xiamen, Peoples R China; 3.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Pathol, Hangzhou, Peoples R China; 4.Xiamen Univ, Zhong Shan Hosp, Dept Gastrointestinal Surg, Xiamen, Peoples R China; 5.Fujian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Fuzhou, Peoples R China; 6.Sun Yat Sen Univ, Affiliated Hosp 6, Dept Gastroenterol, Guangzhou, Peoples R China
推荐引用方式 GB/T 7714	Wang, Ruicong,Li, Hongda,Wu, Jianfeng,et al. Injured adult neurons regress to an embryonic transcriptional growth state[J]. NATURE,2020,581(7806):77-+.
APA	Wang, Ruicong.,Li, Hongda.,Wu, Jianfeng.,Cai, Zhi-Yu.,Li, Baizhou.,...&Mo, Wei.(2020).Injured adult neurons regress to an embryonic transcriptional growth state.NATURE,581(7806),77-+.
MLA	Wang, Ruicong,et al."Injured adult neurons regress to an embryonic transcriptional growth state".NATURE 581.7806(2020):77-+.