| DOI | 10.1038/s41586-019-1850-7
|
| Field-resolved infrared spectroscopy of biological systems |
| Pupeza, Ioachim1,2; Huber, Marinus1,2; Trubetskov, Michael2; Schweinberger, Wolfgang1,3; Hussain, Syed A.1,2; Hofer, Christina1,2; Fritsch, Kilian1; Poetzlberger, Markus2; Vamos, Lenard2; Fill, Ernst1; Amotchkina, Tatiana1; Kepesidis, Kosmas V.1; Apolonski, Alexander1; Karpowicz, Nicholas2; Pervak, Vladimir1,2; Pronin, Oleg1,2; Fleischmann, Frank2,4; Azzeer, Abdallah3; Zigman, Mihaela1,2,4; Krausz, Ferenc1,2,4
|
| 2020-05-01
|
| 发表期刊 | NATURE
 |
| ISSN | 0028-0836
|
| EISSN | 1476-4687
|
| 出版年 | 2020
|
| 卷号 | 577期号:7788页码:52-+ |
| 文章类型 | Article
|
| 语种 | 英语
|
| 国家 | Germany; Saudi Arabia; Hungary |
| 英文关键词 | The proper functioning of living systems and physiological phenotypes depends on molecular composition. Yet simultaneous quantitative detection of a wide variety of molecules remains a challenge(1-8). Here we show how broadband optical coherence opens up opportunities for fingerprinting complex molecular ensembles in their natural environment. Vibrationally excited molecules emit a coherent electric field following few-cycle infrared laser excitation(9-12), and this field is specific to the sample'
s molecular composition. Employing electro-optic sampling(10,12-15), we directly measure this global molecular fingerprint down to field strengths 10(7) times weaker than that of the excitation. This enables transillumination of intact living systems with thicknesses of the order of 0.1 millimetres, permitting broadband infrared spectroscopic probing of human cells and plant leaves. In a proof-of-concept analysis of human blood serum, temporal isolation of the infrared electric-field fingerprint from its excitation along with its sampling with attosecond timing precision results in detection sensitivity of submicrograms per millilitre of blood serum and a detectable dynamic range of molecular concentration exceeding 10(5). This technique promises improved molecular sensitivity and molecular coverage for probing complex, real-world biological and medical settings.
|
| 领域 | 地球科学
; 气候变化
; 资源环境
|
| 收录类别 | SCI-E
|
| WOS记录号 | WOS:000505617400025
|
| WOS关键词 | QUANTITATIVE-ANALYSIS
; SERUM
; SENSITIVITY
; SUPPRESSION
; MOLECULES
; GLUCOSE
; PULSES
|
| WOS类目 | Multidisciplinary Sciences
|
| WOS研究方向 | Science & Technology - Other Topics
|
| 引用统计 |
|
| 文献类型 | 期刊论文
|
| 条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/281097
|
| 专题 | 地球科学
资源环境科学
气候变化
|
| 作者单位 | 1.Ludwig Maximilians Univ Munchen, Garching, Germany;
2.Max Planck Inst Quantum Opt, Garching, Germany;
3.King Saud Univ, Dept Phys & Astron, Riyadh, Saudi Arabia;
4.Ctr Mol Fingerprinting, Budapest, Hungary
|
推荐引用方式
GB/T 7714 |
Pupeza, Ioachim,Huber, Marinus,Trubetskov, Michael,et al. Field-resolved infrared spectroscopy of biological systems[J].
NATURE,2020,577(7788):52-+.
|
| APA |
Pupeza, Ioachim.,Huber, Marinus.,Trubetskov, Michael.,Schweinberger, Wolfgang.,Hussain, Syed A..,...&Krausz, Ferenc.(2020).Field-resolved infrared spectroscopy of biological systems.NATURE,577(7788),52-+.
|
| MLA |
Pupeza, Ioachim,et al."Field-resolved infrared spectroscopy of biological systems".NATURE 577.7788(2020):52-+.
|
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