The emergence of transcriptional identity in somatosensory neurons

doi:10.1038/s41586-019-1900-1

GSTDTAP > 地球科学

DOI	10.1038/s41586-019-1900-1
	The emergence of transcriptional identity in somatosensory neurons
	Sharma, Nikhil 1,2; Flaherty, Kali 1,2; Lezgiyeva, Karina 1,2; Wagner, Daniel E.3; Klein, Allon M.3; Ginty, David D.1,2
	2020-01-09
发表期刊	NATURE
ISSN	0028-0836
EISSN	1476-4687
出版年	2020
卷号	577 期号:7790 页码:392-+
文章类型	Article
语种	英语
国家	USA
英文关键词	More than twelve morphologically and physiologically distinct subtypes of primary somatosensory neuron report salient features of our internal and external environments(1-4). It is unclear how specialized gene expression programs emerge during development to endow these subtypes with their unique properties. To assess the developmental progression of transcriptional maturation of each subtype of principal somatosensory neuron, we generated a transcriptomic atlas of cells traversing the primary somatosensory neuron lineage in mice. Here we show that somatosensory neurogenesis gives rise to neurons in a transcriptionally unspecialized state, characterized by co-expression of transcription factors that become restricted to select subtypes as development proceeds. Single-cell transcriptomic analyses of sensory neurons from mutant mice lacking transcription factors suggest that these broad-to-restricted transcription factors coordinate subtype-specific gene expression programs in subtypes in which their expression is maintained. We also show that neuronal targets are involved in this process disruption of the prototypic target-derived neurotrophic factor NGF leads to aberrant subtype-restricted patterns of transcription factor expression. Our findings support a model in which cues that emanate from intermediate and final target fields promote neuronal diversification in part by transitioning cells from a transcriptionally unspecialized state to transcriptionally distinct subtypes by modulating the selection of subtype-restricted transcription factors.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000509570100037
WOS关键词	PRIMARY AFFERENT-FIBERS ; ROOT GANGLION NEURONS ; MOLECULAR-MECHANISMS ; PRENATAL DEVELOPMENT ; SENSORY NEURONS ; TRP CHANNELS ; GENE ; SPECIFICATION ; EXPRESSION ; RUNX3
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/281067
专题	地球科学资源环境科学气候变化
作者单位	1.Harvard Med Sch, Dept Neurobiol, Boston, MA 02115 USA; 2.Harvard Med Sch, Howard Hughes Med Inst, Boston, MA 02115 USA; 3.Harvard Med Sch, Dept Syst Biol, Boston, MA 02115 USA
推荐引用方式 GB/T 7714	Sharma, Nikhil,Flaherty, Kali,Lezgiyeva, Karina,et al. The emergence of transcriptional identity in somatosensory neurons[J]. NATURE,2020,577(7790):392-+.
APA	Sharma, Nikhil,Flaherty, Kali,Lezgiyeva, Karina,Wagner, Daniel E.,Klein, Allon M.,&Ginty, David D..(2020).The emergence of transcriptional identity in somatosensory neurons.NATURE,577(7790),392-+.
MLA	Sharma, Nikhil,et al."The emergence of transcriptional identity in somatosensory neurons".NATURE 577.7790(2020):392-+.