Cortical pattern generation during dexterous movement is input-driven

doi:10.1038/s41586-019-1869-9

GSTDTAP > 地球科学

DOI	10.1038/s41586-019-1869-9
	Cortical pattern generation during dexterous movement is input-driven
	Cyranoski, David
	2020-06-01
发表期刊	NATURE
ISSN	0028-0836
EISSN	1476-4687
出版年	2020
卷号	577 期号:7790 页码:386-+
文章类型	Article
语种	英语
国家	USA
英文关键词	The motor cortex controls skilled arm movement by sending temporal patterns of activity to lower motor centres(1). Local cortical dynamics are thought to shape these patterns throughout movement execution(2-4). External inputs have been implicated in setting the initial state of the motor cortex(5,6), but they may also have a pattern-generating role. Here we dissect the contribution of local dynamics and inputs to cortical pattern generation during a prehension task in mice. Perturbing cortex to an aberrant state prevented movement initiation, but after the perturbation was released, cortex either bypassed the normal initial state and immediately generated the pattern that controls reaching or failed to generate this pattern. The difference in these two outcomes was probably a result of external inputs. We directly investigated the role of inputs by inactivating the thalamus this perturbed cortical activity and disrupted limb kinematics at any stage of the movement. Activation of thalamocortical axon terminals at different frequencies disrupted cortical activity and arm movement in a graded manner. Simultaneous recordings revealed that both thalamic activity and the current state of cortex predicted changes in cortical activity. Thus, the pattern generator for dexterous arm movement is distributed across multiple, strongly interacting brain regions.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000509570100036
WOS关键词	MOTOR CORTEX ; FUNCTIONAL-ORGANIZATION ; PREMOTOR CORTEX ; CEREBRAL-CORTEX ; NEURAL ACTIVITY ; ARM MOVEMENTS ; DYNAMICS ; THALAMUS ; REPRESENTATIONS ; COORDINATION
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/280988
专题	地球科学资源环境科学气候变化
推荐引用方式 GB/T 7714	Cyranoski, David. Cortical pattern generation during dexterous movement is input-driven[J]. NATURE,2020,577(7790):386-+.
APA	Cyranoski, David.(2020).Cortical pattern generation during dexterous movement is input-driven.NATURE,577(7790),386-+.
MLA	Cyranoski, David."Cortical pattern generation during dexterous movement is input-driven".NATURE 577.7790(2020):386-+.