Feeding-dependent VIP neuron-ILC3 circuit regulates the intestinal barrier

doi:10.1038/s41586-020-2039-9

GSTDTAP > 地球科学

DOI	10.1038/s41586-020-2039-9
	Feeding-dependent VIP neuron-ILC3 circuit regulates the intestinal barrier
	Bhaduri, Aparna 1,2; Andrews, Madeline G.1,2; Mancia Leon, Walter 2; Jung, Diane 1,2; Shin, David 1,3; Allen, Denise 1,3; Jung, Dana 1,2; Schmunk, Galina 1,3; Haeussler, Maximilian 4; Salma, Jahan 5; Pollen, Alex A.1,2; Nowakowski, Tomasz J.1,3; Kriegstein, Arnold R.1,2
	2020-01-29
发表期刊	NATURE
ISSN	0028-0836
EISSN	1476-4687
出版年	2020
卷号	579 期号:7800 页码:575-+
文章类型	Article
语种	英语
国家	USA
英文关键词	The intestinal mucosa serves both as a conduit for the uptake of food-derived nutrients and microbiome-derived metabolites, and as a barrier that prevents tissue invasion by microorganisms and tempers inflammatory responses to the myriad contents of the lumen. How the intestine coordinates physiological and immune responses to food consumption to optimize nutrient uptake while maintaining barrier functions remains unclear. Here we show in mice how a gut neuronal signal triggered by food intake is integrated with intestinal antimicrobial and metabolic responses that are controlled by type-3 innate lymphoid cells (ILC3)(1-3). Food consumption rapidly activates a population of enteric neurons that express vasoactive intestinal peptide (VIP)(4). Projections of VIP-producing neurons (VIPergic neurons) in the lamina propria are in close proximity to clusters of ILC3 that selectively express VIP receptor type 2 (VIPR2 also known as VPAC2). Production of interleukin (IL)-22 by ILC3, which is upregulated by the presence of commensal microorganisms such as segmented filamentous bacteria(5-7), is inhibited upon engagement of VIPR2. As a consequence, levels of antimicrobial peptide derived from epithelial cells are reduced but the expression of lipid-binding proteins and transporters is increased(8). During food consumption, the activation of VIPergic neurons thus enhances the growth of segmented filamentous bacteria associated with the epithelium, and increases lipid absorption. Our results reveal a feeding- and circadian-regulated dynamic neuroimmune circuit in the intestine that promotes a trade-off between innate immune protection mediated by IL-22 and the efficiency of nutrient absorption. Modulation of this pathway may therefore be effective for enhancing resistance to enteropathogens(2,3,9) and for the treatment of metabolic diseases. Feeding controls a neuroimmune circuit comprising VIP-producing neurons and type-3 innate lymphoid cells that helps to regulate the efficiency of nutrient uptake and IL-22-mediated immune protection in the intestine.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000519162400001
WOS关键词	INNATE LYMPHOID-CELLS ; NEURONAL REGULATION ; MICROBIOTA ; PEPTIDE ; MACROPHAGES ; GENERATION ; RECEPTOR
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/280951
专题	地球科学资源环境科学气候变化
作者单位	1.Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA; 2.Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94143 USA; 3.Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA; 4.Univ Calif Santa Cruz, Genom Inst, Santa Cruz, CA 95064 USA; 5.Aga Khan Univ, Ctr Regenerat Med & Stem Cell Res, Karachi, Pakistan
推荐引用方式 GB/T 7714	Bhaduri, Aparna,Andrews, Madeline G.,Mancia Leon, Walter,et al. Feeding-dependent VIP neuron-ILC3 circuit regulates the intestinal barrier[J]. NATURE,2020,579(7800):575-+.
APA	Bhaduri, Aparna.,Andrews, Madeline G..,Mancia Leon, Walter.,Jung, Diane.,Shin, David.,...&Kriegstein, Arnold R..(2020).Feeding-dependent VIP neuron-ILC3 circuit regulates the intestinal barrier.NATURE,579(7800),575-+.
MLA	Bhaduri, Aparna,et al."Feeding-dependent VIP neuron-ILC3 circuit regulates the intestinal barrier".NATURE 579.7800(2020):575-+.