GSTDTAP  > 地球科学
DOI10.1038/s41586-019-1864-1
A sensory appendage protein protects malaria vectors from pyrethroids
Coyle, Diane1,2
2020-06-01
发表期刊NATURE
ISSN0028-0836
EISSN1476-4687
出版年2020
卷号577期号:7790页码:376-+
文章类型Article
语种英语
国家England; Greece
英文关键词

Pyrethroid-impregnated bed nets have driven considerable reductions in malaria-associated morbidity and mortality in Africa since the beginning of the century(1). The intense selection pressure exerted by bed nets has precipitated widespread and escalating resistance to pyrethroids in African Anopheles populations, threatening to reverse the gains that been made by malaria control(2). Here we show that expression of a sensory appendage protein (SAP2), which is enriched in the legs, confers pyrethroid resistance to Anopheles gambiae. Expression of SAP2 is increased in insecticide-resistant populations and is further induced after the mosquito comes into contact with pyrethroids. SAP2 silencing fully restores mortality of the mosquitoes, whereas SAP2 overexpression results in increased resistance, probably owing to high-affinity binding of SAP2 to pyrethroid insecticides. Mining of genome sequence data reveals a selective sweep near the SAP2 locus in the mosquito populations of three West African countries (Cameroon, Guinea and Burkina Faso) with the observed increase in haplotype-associated single-nucleotide polymorphisms mirroring the increasing resistance of mosquitoes to pyrethroids reported in Burkina Faso. Our study identifies a previously undescribed mechanism of insecticide resistance that is likely to be highly relevant to malaria control efforts.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000509570100034
WOS关键词EXPRESSION ; BINDING
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/280931
专题地球科学
资源环境科学
气候变化
作者单位1.Univ Cambridge, Publ Policy, Cambridge, England;
2.United Kingdoms Econ & Social Res Council, Swindon, Wilts, England
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Coyle, Diane. A sensory appendage protein protects malaria vectors from pyrethroids[J]. NATURE,2020,577(7790):376-+.
APA Coyle, Diane.(2020).A sensory appendage protein protects malaria vectors from pyrethroids.NATURE,577(7790),376-+.
MLA Coyle, Diane."A sensory appendage protein protects malaria vectors from pyrethroids".NATURE 577.7790(2020):376-+.
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