Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1002/2016GL072007 |
Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution | |
Rutledge, Gavin G.1; Bohme, Ulrike1,11; Sanders, Mandy1,3,5,8,9,10,13; Rrid, Adam J.1,7,12; Cotton, James A.1,4,6; Maiga-Ascofare, Oumou2; Djimde, Abdoulaye A.1,8,10,12; Apinjoh, Tobias O.3,5,9; Amenga-Etego, Lucas2,6; Manske, Magnus1,4,8; Barnwell, John W.2,7,10,12; Renaud, Francois7,13; Ollomo, Benjamin6,7; Prugnolle, Franck7,8,10; Anstey, Nicholas M.6,9; Auburn, Sarah3,4,7; Price, Ric N.4,8; McCarthy, James S.5,12,13; Kwiatkowski, Dominic P.12; Newbold, Chris I.13; Berriman, Matthew1,11; Otto, Thomas D.1 | |
2017-02-02 | |
发表期刊 | NATURE |
ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2017 |
卷号 | 542期号:7639页码:101-+ |
文章类型 | Article |
语种 | 英语 |
国家 | England; Mali; Germany; Cameroon; Ghana; USA; France; Gabon; Australia |
英文摘要 | Elucidation of the evolutionary history and interrelatedness of Plasmodium species that infect humans has been hampered by a lack of genetic information for three human-infective species: P. malariae and two P. ovale species (P. o. curtisi and P. o. wallikeri)(1). These species are prevalent across most regions in which malaria is endemic(2,3) and are often undetectable by light microscopy(4), rendering their study in human populations difficult(5). The exact evolutionary relationship of these species to the other human-infective species has been contested(6,7). Using a new reference genome for P. malariae and a manually curated draft P. o. curtisi genome, we are now able to accurately place these species within the Plasmodium phylogeny. Sequencing of a P. malariae relative that infects chimpanzees reveals similar signatures of selection in the P. malariae lineage to another Plasmodium lineage shown to be capable of colonization of both human and chimpanzee hosts. Molecular dating suggests that these host adaptations occurred over similar evolutionary timescales. In addition to the core genome that is conserved between species, differences in gene content can be linked to their specific biology. The genome suggests that P. malariae expresses a family of heterodimeric proteins on its surface that have structural similarities to a protein crucial for invasion of red blood cells. The data presented here provide insight into the evolution of the Plasmodium genus as a whole. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000396119300039 |
WOS关键词 | GENE-EXPRESSION ; I-TASSER ; SEQUENCE ; ALGORITHM ; ALIGNMENT ; FAMILIES ; BRASILIANUM ; PHYLOGENIES ; GENERATION ; ASSEMBLIES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/28009 |
专题 | 气候变化 |
作者单位 | 1.Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England; 2.Univ Sci Techn & Technol Bamako, Malaria Res & Training Ctr, BP E 2528, Bamako, Mali; 3.German Ctr Infect Res, D-20359 Hamburg, Germany; 4.Univ Buea, Post Off Box 63, Buea, South West Regi, Cameroon; 5.Navrongo Hlth Res Ctr, Post Off Box 114, Navrongo, Upper East Regi, Ghana; 6.Ctr Dis Control & Prevent, Atlanta, GA 30333 USA; 7.UM1 CNRS IRD, Lab MIVEGEC, F-34394 Montpellier, France; 8.Ctr Int Recherches Med Franceville, BP 709 Franceville, Franceville, Gabon; 9.Menzies Sch Hlth Res & Charles Darwin Univ, Global & Trop Hlth Div, Darwin, NT, Australia; 10.Univ Oxford, Nuffield Dept Clin Med, Ctr Top Med & Global Hlth, Oxford OX3 7LJ, England; 11.Univ Queensland, QIMR Berghofer Med Res Inst, Clin Trop Med Lab, Brisbane, Qld, Australia; 12.Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England; 13.Univ Oxford, Inst Mol Med, John Radcliffe Hosp, Oxford OX3 9DS, England |
推荐引用方式 GB/T 7714 | Rutledge, Gavin G.,Bohme, Ulrike,Sanders, Mandy,et al. Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution[J]. NATURE,2017,542(7639):101-+. |
APA | Rutledge, Gavin G..,Bohme, Ulrike.,Sanders, Mandy.,Rrid, Adam J..,Cotton, James A..,...&Otto, Thomas D..(2017).Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution.NATURE,542(7639),101-+. |
MLA | Rutledge, Gavin G.,et al."Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution".NATURE 542.7639(2017):101-+. |
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